ID   6.1.1.26
DE   pyrrolysine--tRNA(Pyl) ligase.
AN   PylRS.
AN   pyrrolysyl-tRNA synthetase.
CA   ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-
CA   tRNA(Pyl).
CC   -!- In organisms such as Methanosarcina barkeri that incorporate the
CC       modified amino acid pyrrolysine (Pyl) into certain methylamine
CC       methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon,
CC       can be charged directly with pyrrolysine by this class II aminoacyl-
CC       -tRNA ligase.
CC   -!- Specific for pyrrolysine as substrate as it cannot be replaced by
CC       lysine or any of the other natural amino acids.
DR   Q8TUB8, PYLS_METAC ;  Q6WRH6, PYLS_METBA ;  Q46E77, PYLS_METBF ;
DR   Q12UB6, PYLS_METBU ;  Q8PWY1, PYLS_METMA ;  Q1L6A3, PYLS_METTE ;
//