ENZYME entry: EC 6.1.2.1

Accepted Name
D-alanine--(R)-lactate ligase.
Reaction catalysed
D-alanine + (R)-lactate + ATP <=> D-alanyl-(R)-lactate + ADP + phosphate
Comment(s)
  • The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cross-references
BRENDA6.1.2.1
EC2PDB6.1.2.1
ExplorEnz6.1.2.1
PRIAM enzyme-specific profiles6.1.2.1
KEGG Ligand Database for Enzyme Nomenclature6.1.2.1
IUBMB Enzyme Nomenclature6.1.2.1
IntEnz6.1.2.1
MEDLINEFind literature relating to 6.1.2.1
MetaCyc6.1.2.1
UniProtKB/Swiss-Prot
P25051, VANA_ENTFC;  Q06893, VANB_ENTFA;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-