ENZYME entry: EC 6.1.2.1
| Accepted Name |
|---|
| D-alanine--(R)-lactate ligase.
|
| Reaction catalysed |
|---|
| D-alanine + (R)-lactate + ATP <=> D-alanyl-(R)-lactate + ADP + phosphate |
| Comment(s) |
|---|
- The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate,
can be incorporated into the peptidoglycan pentapeptide instead of
the usual D-alanyl-D-alanine dipeptide, which is formed by
EC 6.3.2.4.
- The resulting peptidoglycan does not bind the glycopeptide
antibiotics vancomycin and teicoplanin, conferring resistance on the
bacteria.
|
| Cross-references |
|---|
| BRENDA | 6.1.2.1 |
| EC2PDB | 6.1.2.1 |
| ExplorEnz | 6.1.2.1 |
| PRIAM enzyme-specific profiles | 6.1.2.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.1.2.1 |
| IUBMB Enzyme Nomenclature | 6.1.2.1 |
| IntEnz | 6.1.2.1 |
| MEDLINE | Find literature relating to 6.1.2.1 |
| MetaCyc | 6.1.2.1 |
| UniProtKB/Swiss-Prot |
|
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