Due to maintenance work, this service will not be available on Monday December 12th between 07.00 am and 9.00 am CEST.

ENZYME entry: EC 6.2.1.19

Accepted Name
Long-chain-fatty-acid--protein ligase.
Alternative Name(s)
Acyl-protein synthetase.
Reaction catalysed
ATP + a long-chain fatty acid + [protein]-L-cysteine <=> AMP + diphosphate + a [protein]-S-(long-chain-acyl)-L-cysteine
Comment(s)
  • Together with a hydrolase component (EC 3.1.2.2/3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3).
  • The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue.
  • It then transfers the acyl group to EC 1.2.1.50.
Cross-references
BRENDA6.2.1.19
EC2PDB6.2.1.19
ExplorEnz6.2.1.19
PRIAM enzyme-specific profiles6.2.1.19
KEGG Ligand Database for Enzyme Nomenclature6.2.1.19
IUBMB Enzyme Nomenclature6.2.1.19
IntEnz6.2.1.19
MEDLINEFind literature relating to 6.2.1.19
MetaCyc6.2.1.19
UniProtKB/Swiss-Prot
P24272, LUXE_ALIFS;  P29334, LUXE_PHOLE;  P19842, LUXE_PHOLU;  
P14286, LUXE_VIBHA;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-