ENZYME entry: EC 6.2.1.3

Accepted Name
Long-chain-fatty-acid--CoA ligase.
Alternative Name(s)
Acyl-activating enzyme.
Acyl-CoA synthetase.
Fatty acid thiokinase (long chain).
Lignoceroyl-CoA synthase.
Reaction catalysed
ATP + a long-chain carboxylic acid + CoA <=> AMP + diphosphate + an acyl-CoA
Comment(s)
  • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
  • The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
Cross-references
PROSITEPDOC00427
BRENDA6.2.1.3
EC2PDB6.2.1.3
ExplorEnz6.2.1.3
PRIAM enzyme-specific profiles6.2.1.3
KEGG Ligand Database for Enzyme Nomenclature6.2.1.3
IUBMB Enzyme Nomenclature6.2.1.3
IntEnz6.2.1.3
MEDLINEFind literature relating to 6.2.1.3
MetaCyc6.2.1.3
UniProtKB/Swiss-Prot
Q2KHW5, ACBG1_BOVIN;  Q96GR2, ACBG1_HUMAN;  Q4R4P9, ACBG1_MACFA;  
Q99PU5, ACBG1_MOUSE;  Q924N5, ACBG1_RAT;  Q5ZKR7, ACBG2_CHICK;  
Q5FVE4, ACBG2_HUMAN;  Q2XU92, ACBG2_MOUSE;  A1L1K7, ACBG2_RAT;  
Q7ZYC4, ACBG2_XENLA;  Q9JID6, ACSL1_CAVPO;  P33121, ACSL1_HUMAN;  
P41216, ACSL1_MOUSE;  P18163, ACSL1_RAT;  O95573, ACSL3_HUMAN;  
Q9CZW4, ACSL3_MOUSE;  Q5R668, ACSL3_PONAB;  Q63151, ACSL3_RAT;  
O60488, ACSL4_HUMAN;  Q9QUJ7, ACSL4_MOUSE;  O35547, ACSL4_RAT;  
Q9ULC5, ACSL5_HUMAN;  Q8JZR0, ACSL5_MOUSE;  O88813, ACSL5_RAT;  
Q9UKU0, ACSL6_HUMAN;  Q91WC3, ACSL6_MOUSE;  P33124, ACSL6_RAT;  
Q9V3U0, BGML_DROME;  Q9V3S9, BGM_DROME;  Q7TYX8, FAC15_MYCBO;  
B2HGV4, FAC15_MYCMM;  O53521, FAC15_MYCTU;  Q7TWC5, FAC17_MYCBO;  
B2HHZ8, FAC17_MYCMM;  O53551, FAC17_MYCTU;  Q7TWB7, FAC19_MYCBO;  
B2HI05, FAC19_MYCMM;  Q7D5D8, FAC19_MYCTU;  Q7TVK7, FAC23_MYCBO;  
O07797, FAC23_MYCTU;  Q55DR6, FCSA_DICDI;  Q1ZXQ4, FCSB_DICDI;  
O22898, LACS1_ARATH;  Q9XIA9, LACS2_ARATH;  Q9C7W4, LACS3_ARATH;  
Q9T0A0, LACS4_ARATH;  Q9T009, LACS5_ARATH;  Q8LPS1, LACS6_ARATH;  
Q8LKS5, LACS7_ARATH;  Q9SJD4, LACS8_ARATH;  Q9CAP8, LACS9_ARATH;  
O60135, LCF1_SCHPO;  P30624, LCF1_YEAST;  Q9P7D7, LCF2_SCHPO;  
P39518, LCF2_YEAST;  P39002, LCF3_YEAST;  P47912, LCF4_YEAST;  
P94547, LCFA_BACSU;  Q8XDR6, LCFA_ECO57;  P69452, LCFA_ECOL6;  
P69451, LCFA_ECOLI;  P46450, LCFA_HAEIN;  P63522, LCFA_SALTI;  
P63521, LCFA_SALTY;  Q8ZES9, LCFA_YERPE;  O07610, LCFB_BACSU;  
P44446, LCFH_HAEIN;  O14975, S27A2_HUMAN;  O35488, S27A2_MOUSE;  
P97524, S27A2_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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