Expasy logo

ENZYME

ENZYME entry: EC 6.2.1.3

Accepted Name
long-chain-fatty-acid--CoA ligase
Alternative Name(s)
acyl-activating enzyme
acyl-CoA synthetase
fatty acid thiokinase (long chain)
lignoceroyl-CoA synthase
Reaction catalysed
a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate
Comment(s)
  • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
  • The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.
Cross-references
BRENDA6.2.1.3
EC2PDB6.2.1.3
ExplorEnz6.2.1.3
PRIAM enzyme-specific profiles6.2.1.3
KEGG Ligand Database for Enzyme Nomenclature6.2.1.3
IUBMB Enzyme Nomenclature6.2.1.3
IntEnz6.2.1.3
MEDLINEFind literature relating to 6.2.1.3
MetaCyc6.2.1.3
Rhea expert-curated reactions6.2.1.3
UniProtKB/Swiss-Prot
Q2KHW5, ACBG1_BOVINQ96GR2, ACBG1_HUMANQ4R4P9, ACBG1_MACFA
Q99PU5, ACBG1_MOUSEQ924N5, ACBG1_RATQ5ZKR7, ACBG2_CHICK
Q5FVE4, ACBG2_HUMANQ2XU92, ACBG2_MOUSEA1L1K7, ACBG2_RAT
Q7ZYC4, ACBG2_XENLAQ9JID6, ACSL1_CAVPOP33121, ACSL1_HUMAN
P41216, ACSL1_MOUSEP18163, ACSL1_RATO95573, ACSL3_HUMAN
Q9CZW4, ACSL3_MOUSEQ5R668, ACSL3_PONABQ63151, ACSL3_RAT
O60488, ACSL4_HUMANQ9QUJ7, ACSL4_MOUSEO35547, ACSL4_RAT
Q9ULC5, ACSL5_HUMANQ8JZR0, ACSL5_MOUSEO88813, ACSL5_RAT
Q9UKU0, ACSL6_HUMANQ91WC3, ACSL6_MOUSEP33124, ACSL6_RAT
Q9V3S9, BGM_DROMEP9WQ36, FAC13_MYCTOP9WQ37, FAC13_MYCTU
Q7TYX8, FAC15_MYCBOB2HGV4, FAC15_MYCMMO53521, FAC15_MYCTU
Q7TWC5, FAC17_MYCBOB2HHZ8, FAC17_MYCMMO53551, FAC17_MYCTU
Q7TWB7, FAC19_MYCBOB2HI05, FAC19_MYCMMA0R4Q2, FAC19_MYCS2
P9WQ50, FAC19_MYCTOP9WQ51, FAC19_MYCTUO05307, FAC6_MYCTU
O06417, FAC8_MYCTUQ55DR6, FCSA_DICDIQ1ZXQ4, FCSB_DICDI
Q9V3U0, HMLL_DROMEO22898, LACS1_ARATHQ9XIA9, LACS2_ARATH
Q9C7W4, LACS3_ARATHQ9T0A0, LACS4_ARATHQ9T009, LACS5_ARATH
Q8LPS1, LACS6_ARATHQ8LKS5, LACS7_ARATHQ9SJD4, LACS8_ARATH
Q9CAP8, LACS9_ARATHO60135, LCF1_SCHPOP30624, LCF1_YEAST
Q9P7D7, LCF2_SCHPOP39518, LCF2_YEASTP39002, LCF3_YEAST
P47912, LCF4_YEASTP94547, LCFA_BACSUQ8XDR6, LCFA_ECO57
P69452, LCFA_ECOL6P69451, LCFA_ECOLIP46450, LCFA_HAEIN
P63522, LCFA_SALTIP63521, LCFA_SALTYQ8ZES9, LCFA_YERPE
O07610, LCFB_BACSUQ5SKN9, LCFCS_THET8P44446, LCFH_HAEIN
Q3ZKN0, S27A1_BOVINQ6PCB7, S27A1_HUMANQ60714, S27A1_MOUSE
P97849, S27A1_RATO14975, S27A2_HUMANO35488, S27A2_MOUSE
P97524, S27A2_RATQ5K4L6, S27A3_HUMANO88561, S27A3_MOUSE
Q6P1M0, S27A4_HUMANQ4R3Y4, S27A4_MACFAQ91VE0, S27A4_MOUSE
Q5RDY4, S27A4_PONABQ9Y2P5, S27A5_HUMANQ4LDG0, S27A5_MOUSE
Q9ES38, S27A5_RATQ9Y2P4, S27A6_HUMANE9Q9W4, S27A6_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-