ID 6.2.1.3 DE Long-chain-fatty-acid--CoA ligase. AN Acyl-activating enzyme. AN Acyl-CoA synthetase. AN Fatty acid thiokinase (long chain). AN Lignoceroyl-CoA synthase. CA ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. CC -!- Acts on a wide range of long-chain saturated and unsaturated fatty CC acids, but the enzymes from different tissues show some variation in CC specificity. CC -!- The liver enzyme acts on acids from C(6) to C(20); that from brain CC shows high activity up to C(24). PR PROSITE; PDOC00427; DR Q2KHW5, ACBG1_BOVIN; Q96GR2, ACBG1_HUMAN; Q4R4P9, ACBG1_MACFA; DR Q99PU5, ACBG1_MOUSE; Q924N5, ACBG1_RAT ; Q5ZKR7, ACBG2_CHICK; DR Q5FVE4, ACBG2_HUMAN; Q2XU92, ACBG2_MOUSE; A1L1K7, ACBG2_RAT ; DR Q7ZYC4, ACBG2_XENLA; Q9JID6, ACSL1_CAVPO; P33121, ACSL1_HUMAN; DR P41216, ACSL1_MOUSE; P18163, ACSL1_RAT ; O95573, ACSL3_HUMAN; DR Q9CZW4, ACSL3_MOUSE; Q5R668, ACSL3_PONAB; Q63151, ACSL3_RAT ; DR O60488, ACSL4_HUMAN; Q9QUJ7, ACSL4_MOUSE; O35547, ACSL4_RAT ; DR Q9ULC5, ACSL5_HUMAN; Q8JZR0, ACSL5_MOUSE; O88813, ACSL5_RAT ; DR Q9UKU0, ACSL6_HUMAN; Q91WC3, ACSL6_MOUSE; P33124, ACSL6_RAT ; DR Q9V3U0, BGML_DROME ; Q9V3S9, BGM_DROME ; Q7TYX8, FAC15_MYCBO; DR B2HGV4, FAC15_MYCMM; O53521, FAC15_MYCTU; Q7TWC5, FAC17_MYCBO; DR B2HHZ8, FAC17_MYCMM; O53551, FAC17_MYCTU; Q7TWB7, FAC19_MYCBO; DR B2HI05, FAC19_MYCMM; Q7D5D8, FAC19_MYCTU; Q7TVK7, FAC23_MYCBO; DR O07797, FAC23_MYCTU; Q55DR6, FCSA_DICDI ; Q1ZXQ4, FCSB_DICDI ; DR O22898, LACS1_ARATH; Q9XIA9, LACS2_ARATH; Q9C7W4, LACS3_ARATH; DR Q9T0A0, LACS4_ARATH; Q9T009, LACS5_ARATH; Q8LPS1, LACS6_ARATH; DR Q8LKS5, LACS7_ARATH; Q9SJD4, LACS8_ARATH; Q9CAP8, LACS9_ARATH; DR O60135, LCF1_SCHPO ; P30624, LCF1_YEAST ; Q9P7D7, LCF2_SCHPO ; DR P39518, LCF2_YEAST ; P39002, LCF3_YEAST ; P47912, LCF4_YEAST ; DR P94547, LCFA_BACSU ; Q8XDR6, LCFA_ECO57 ; P69452, LCFA_ECOL6 ; DR P69451, LCFA_ECOLI ; P46450, LCFA_HAEIN ; P63522, LCFA_SALTI ; DR P63521, LCFA_SALTY ; Q8ZES9, LCFA_YERPE ; O07610, LCFB_BACSU ; DR P44446, LCFH_HAEIN ; O14975, S27A2_HUMAN; O35488, S27A2_MOUSE; DR P97524, S27A2_RAT ; //