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ENZYME entry: EC

Accepted Name
3-hydroxypropionyl-CoA synthase.
Alternative Name(s)
3-hydroxypropionate--CoA ligase.
3-hydroxypropionyl-CoA synthetase (AMP-forming).
Reaction catalysed
3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropionyl-CoA + AMP + diphosphate
  • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
  • The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propanoate, acrylate, acetate, and butanoate as substrates, and are thus different from EC, which does not accept acetate or butanoate.
PRIAM enzyme-specific profiles6.2.1.36
KEGG Ligand Database for Enzyme Nomenclature6.2.1.36
IUBMB Enzyme Nomenclature6.2.1.36
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