ENZYME entry: EC 6.2.1.39

Accepted Name
[Butirosin acyl-carrier protein]--L-glutamate ligase.
Alternative Name(s)
[BtrI acyl-carrier protein]--L-glutamate ligase.
Reaction catalysed
  • ATP + L-glutamate + [BtrI acyl-carrier protein] <=> ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
  • ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] <=> ADP + phosphate + 4-(L-gamma-glutamylamino)butanoyl-[BtrI acyl-carrier protein]
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • Catalyzes two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
  • The enzyme adds one molecule of L-glutamate to a dedicated acyl- carrier protein, and following decarboxylation of the product by EC 4.1.1.95, adds a second L-glutamate molecule.
Cross-references
BRENDA6.2.1.39
EC2PDB6.2.1.39
ExplorEnz6.2.1.39
PRIAM enzyme-specific profiles6.2.1.39
KEGG Ligand Database for Enzyme Nomenclature6.2.1.39
IUBMB Enzyme Nomenclature6.2.1.39
IntEnz6.2.1.39
MEDLINEFind literature relating to 6.2.1.39
MetaCyc6.2.1.39
UniProtKB/Swiss-Prot
Q4H4E7, BTRJ_BACCI

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-