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ENZYME entry: EC

Accepted Name
[Butirosin acyl-carrier protein]--L-glutamate ligase.
Alternative Name(s)
[BtrI acyl-carrier protein]--L-glutamate ligase.
Reaction catalysed
  • ATP + L-glutamate + [BtrI acyl-carrier protein] <=> ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
  • ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] <=> ADP + phosphate + 4-(L-gamma-glutamylamino)butanoyl-[BtrI acyl-carrier protein]
Mn(2+) or Mg(2+).
  • Catalyzes two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
  • The enzyme adds one molecule of L-glutamate to a dedicated acyl- carrier protein, and following decarboxylation of the product by EC, adds a second L-glutamate molecule.
PRIAM enzyme-specific profiles6.2.1.39
KEGG Ligand Database for Enzyme Nomenclature6.2.1.39
IUBMB Enzyme Nomenclature6.2.1.39
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