ENZYME entry: EC 6.2.1.42

Accepted Name
3-oxocholest-4-en-26-oate--CoA ligase.
Reaction catalysed
ATP + (25S)-3-oxocholest-4-en-26-oate + CoA <=> AMP + diphosphate + (25S)-3-oxocholest-4-en-26-oyl-CoA
Comment(s)
  • The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol.
  • It is responsible for the activation of the C8 side chain.
  • 3-beta-hydroxycholest-5-en-26-oate can also be used as substrate.
Cross-references
BRENDA6.2.1.42
EC2PDB6.2.1.42
ExplorEnz6.2.1.42
PRIAM enzyme-specific profiles6.2.1.42
KEGG Ligand Database for Enzyme Nomenclature6.2.1.42
IUBMB Enzyme Nomenclature6.2.1.42
IntEnz6.2.1.42
MEDLINEFind literature relating to 6.2.1.42
MetaCyc6.2.1.42
UniProtKB/Swiss-Prot
Q7TWB7, FAC19_MYCBO;  B2HI05, FAC19_MYCMM;  P9WQ50, FAC19_MYCTO;  
P9WQ51, FAC19_MYCTU;  E3UUE6, FAC19_RHORH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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