ENZYME entry: EC 6.2.1.43

Accepted Name
2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase.
Reaction catalysed
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA <=> AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Comment(s)
  • The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1- naphthoate moiety of the antibiotic neocarzinostatin.
  • In vitro the enzyme also catalyzes the activation of other 1-naphthoic acid analogs, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.
Cross-references
BRENDA6.2.1.43
EC2PDB6.2.1.43
ExplorEnz6.2.1.43
PRIAM enzyme-specific profiles6.2.1.43
KEGG Ligand Database for Enzyme Nomenclature6.2.1.43
IUBMB Enzyme Nomenclature6.2.1.43
IntEnz6.2.1.43
MEDLINEFind literature relating to 6.2.1.43
MetaCyc6.2.1.43
UniProtKB/Swiss-Prot
Q84HC5, NCSB2_STRCZ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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