ID   6.2.1.7
DE   cholate--CoA ligase.
AN   3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-
AN   forming).
AN   3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate--CoA ligase.
AN   3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase.
AN   3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase.
AN   3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A
AN   synthetase.
AN   BAL.
AN   bile acid CoA ligase.
AN   bile acid coenzyme A ligase.
AN   cholate thiokinase.
AN   cholic acid:CoA ligase.
AN   cholic thiokinase.
AN   choloyl-CoA synthetase.
AN   choloyl coenzyme A synthetase.
AN   cholyl-CoA synthetase.
AN   THCA-CoA ligase.
AN   trihydroxycoprostanoyl-CoA synthetase.
CA   (1) ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate.
CA   (2) (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate +
CA   ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-
CA   oyl-CoA + AMP + diphosphate.
CC   -!- This membrane-bound enzyme catalyzes the first step in the
CC       conjugation of bile acids with amino acids, converting bile acids
CC       into their acyl-CoA thioesters.
CC   -!- The second step involves EC 2.3.1.65 and converts the acyl-CoA
CC       thioester into the corresponding N-acyl amidate by conjugation with
CC       glycine or taurine.
CC   -!- Chenodeoxycholate, deoxycholate, lithocholate and
CC       trihydroxycoprostanoate can also act as substrates.
CC   -!- Formerly EC 6.2.1.29.
DR   P19409, BAIB_CLOSV ;  O14975, S27A2_HUMAN;  O35488, S27A2_MOUSE;
DR   P97524, S27A2_RAT  ;  Q9Y2P5, S27A5_HUMAN;  Q4LDG0, S27A5_MOUSE;
DR   Q9ES38, S27A5_RAT  ;
//