ID   6.3.1.12
DE   D-aspartate ligase.
AN   Asl(fm).
AN   D-aspartic acid-activating enzyme.
CA   ATP + D-aspartate + (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-
CA   Lys-D-Ala-D-Ala))(n) = (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-
CA   6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala))(n) + ADP + phosphate.
CC   -!- Forms part of the peptidoglycan assembly pathway of Gram-positive
CC       bacteria grown in medium containing D-Asp.
CC   -!- Normally, the side chains the acylate the 6-amino group of the
CC       L-lysine residue contain L-Ala-L-Ala but these amino acids are
CC       replaced by D-Asp when D-Asp is included in the medium.
CC   -!- Hybrid chains containing L-Ala-D-Asp, L-Ala-L-Ala-D-Asp or D-Asp-L-
CC       Ala are not formed.
CC   -!- Highly specific for D-aspartate, as L-aspartate, D-glutamate,
CC       D-alanine, D-iso-asparagine and D-malic acid are not substrates.
CC   -!- In Enterococcus faecium, the substrate D-aspartate is produced by
CC       EC 5.1.1.13.
PR   PROSITE; PDOC50975;
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