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ENZYME entry: EC 6.3.1.13

Accepted Name
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase.
Alternative Name(s)
MshC ligase.
Mycothiol ligase.
Reaction catalysed
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP <=> 1-O-(2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + AMP + diphosphate
Comment(s)
  • This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes.
  • Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics.
  • The enzyme may represent a novel target for new classes of antituberculars.
  • Formerly EC 6.1.1.n1.
Cross-references
BRENDA6.3.1.13
EC2PDB6.3.1.13
ExplorEnz6.3.1.13
PRIAM enzyme-specific profiles6.3.1.13
KEGG Ligand Database for Enzyme Nomenclature6.3.1.13
IUBMB Enzyme Nomenclature6.3.1.13
IntEnz6.3.1.13
MEDLINEFind literature relating to 6.3.1.13
MetaCyc6.3.1.13
UniProtKB/Swiss-Prot
Q4JXD7, MSHC1_CORJK;  B1VEQ2, MSHC1_CORU7;  Q4JVN7, MSHC2_CORJK;  
B1VDU4, MSHC2_CORU7;  A0LU34, MSHC_ACIC1;  C6WIA0, MSHC_ACTMD;  
A0JWX8, MSHC_ARTS2;  C5BVB1, MSHC_BEUC1;  C7MCZ4, MSHC_BRAFD;  
C7Q9B2, MSHC_CATAD;  D5UFA8, MSHC_CELFN;  A5CRN7, MSHC_CLAM3;  
B0RC50, MSHC_CLAMS;  C3PG89, MSHC_CORA7;  Q6NH81, MSHC_CORDI;  
Q8FTD0, MSHC_COREF;  A4QEA0, MSHC_CORGB;  Q8NQC4, MSHC_CORGL;  
C4LIL9, MSHC_CORK4;  Q9FB57, MSHC_CORST;  Q0RLV2, MSHC_FRAAA;  
Q2J9N8, MSHC_FRACC;  A8LH67, MSHC_FRASN;  D2S6C9, MSHC_GEOOG;  
D0LDR0, MSHC_GORB4;  C7R3Z4, MSHC_JONDD;  A6W933, MSHC_KINRD;  
B2GIP6, MSHC_KOCRD;  D2PPT3, MSHC_KRIFD;  C7NHQ9, MSHC_KYTSD;  
C5CBT9, MSHC_MICLC;  A0QF76, MSHC_MYCA1;  B1MPE6, MSHC_MYCA9;  
P67018, MSHC_MYCBO;  A1KKH3, MSHC_MYCBP;  C1AQ46, MSHC_MYCBT;  
A4TB85, MSHC_MYCGI;  B8ZRD9, MSHC_MYCLB;  Q49784, MSHC_MYCLE;  
B2HFY1, MSHC_MYCMM;  Q73YS9, MSHC_MYCPA;  A0QZY0, MSHC_MYCS2;  
A3Q1B7, MSHC_MYCSJ;  A1UHV1, MSHC_MYCSK;  Q1B774, MSHC_MYCSS;  
A5U4F6, MSHC_MYCTA;  A5WPA3, MSHC_MYCTF;  C6DPT0, MSHC_MYCTK;  
P9WJM8, MSHC_MYCTO;  P9WJM9, MSHC_MYCTU;  A0PQV5, MSHC_MYCUA;  
A1TAS3, MSHC_MYCVP;  C8X8S1, MSHC_NAKMY;  D7B412, MSHC_NOCDD;  
Q5YVL0, MSHC_NOCFA;  A1SJZ6, MSHC_NOCSJ;  A1R6P9, MSHC_PAEAT;  
B8H8K8, MSHC_PSECP;  A9WSI9, MSHC_RENSM;  C0ZZW9, MSHC_RHOE4;  
Q0SIC6, MSHC_RHOJR;  C1ASS8, MSHC_RHOOB;  D2NT85, MSHC_ROTMD;  
A4FBV6, MSHC_SACEN;  C7MWX8, MSHC_SACVD;  A8M264, MSHC_SALAI;  
A4X6W9, MSHC_SALTO;  D1BHU9, MSHC_SANKS;  D6ZFG9, MSHC_SEGRD;  
D3Q598, MSHC_STANL;  Q828M2, MSHC_STRAW;  D7BSS4, MSHC_STRBB;  
Q9ADA4, MSHC_STRCO;  B1W2Y7, MSHC_STRGG;  D2AU10, MSHC_STRRD;  
C9Z2Z3, MSHC_STRSW;  D6Y1N8, MSHC_THEBD;  D1A2Q5, MSHC_THECD;  
Q47NV4, MSHC_THEFY;  D5UPJ5, MSHC_TSUPD;  D1BS17, MSHC_XYLCX;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-