ENZYME entry: EC 6.3.1.2

Accepted Name
Glutamine synthetase.
Alternative Name(s)
Glutamate--ammonia ligase.
L-glutamine synthetase.
Reaction catalysed
ATP + L-glutamate + NH(3) <=> ADP + phosphate + L-glutamine
Comment(s)
  • Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life.
  • Several types have been described, differing in their oligomeric structures and cofactor requirements.
Cross-references
PROSITEPDOC00162
BRENDA6.3.1.2
EC2PDB6.3.1.2
ExplorEnz6.3.1.2
PRIAM enzyme-specific profiles6.3.1.2
KEGG Ligand Database for Enzyme Nomenclature6.3.1.2
IUBMB Enzyme Nomenclature6.3.1.2
IntEnz6.3.1.2
MEDLINEFind literature relating to 6.3.1.2
MetaCyc6.3.1.2
UniProtKB/Swiss-Prot
Q56WN1, GLN11_ARATH;  P14656, GLN11_ORYSJ;  Q8LCE1, GLN12_ARATH;  
P14654, GLN12_ORYSJ;  Q9LVI8, GLN13_ARATH;  Q4W8D0, GLN13_ORYSJ;  
Q9FMD9, GLN14_ARATH;  Q8GXW5, GLN15_ARATH;  O29313, GLN1A_ARCFU;  
P19064, GLN1A_BACCE;  P12425, GLN1A_BACSU;  P10656, GLN1A_CLOSA;  
Q9HNI2, GLN1A_HALSA;  P43386, GLN1A_HALVD;  P45627, GLN1A_LACDE;  
Q9CDL9, GLN1A_LACLA;  Q60182, GLN1A_METJA;  O59648, GLN1A_METMP;  
O27612, GLN1A_METTH;  P21154, GLN1A_METVO;  P64246, GLN1A_MYCBO;  
A0R083, GLN1A_MYCS2;  P9WN36, GLN1A_MYCTO;  P9WN37, GLN1A_MYCTU;  
Q9UY99, GLN1A_PYRAB;  Q05907, GLN1A_PYRFU;  O58097, GLN1A_PYRHO;  
P36687, GLN1A_PYRWO;  Q5HGC3, GLN1A_STAAC;  P60890, GLN1A_STAAM;  
P99095, GLN1A_STAAN;  Q6GHC6, GLN1A_STAAR;  Q6G9Q4, GLN1A_STAAS;  
P0A040, GLN1A_STAAU;  P0A039, GLN1A_STAAW;  Q5HPN2, GLN1A_STAEQ;  
Q8CSR8, GLN1A_STAES;  Q9HH09, GLN1A_SULAC;  O08467, GLN1A_THEKO;  
P36205, GLN1A_THEMA;  P07804, GLN1B_ACIFR;  O66514, GLN1B_AQUAE;  
P10583, GLN1B_AZOBR;  P94126, GLN1B_AZOC5;  P22248, GLN1B_AZOVI;  
P05457, GLN1B_BRADU;  P0A9C7, GLN1B_ECO57;  P0A9C6, GLN1B_ECOL6;  
P0A9C5, GLN1B_ECOLI;  P46033, GLN1B_FRAAL;  P43794, GLN1B_HAEIN;  
Q9ZLW5, GLN1B_HELPJ;  P94845, GLN1B_HELPY;  P15124, GLN1B_METCA;  
P33035, GLN1B_MICDP;  P0A591, GLN1B_MYCBO;  A0R079, GLN1B_MYCS2;  
P9WN38, GLN1B_MYCTO;  P9WN39, GLN1B_MYCTU;  P25821, GLN1B_NEIGO;  
P00964, GLN1B_NOSS1;  Q9CLP2, GLN1B_PASMU;  P20479, GLN1B_PHOLP;  
P28786, GLN1B_PROHU;  Q9HU65, GLN1B_PSEAE;  Q3V5W6, GLN1B_PSETA;  
P09826, GLN1B_RHILV;  Q59747, GLN1B_RHIME;  P13499, GLN1B_RHOCA;  
P43518, GLN1B_RHOSH;  P0A1P7, GLN1B_SALTI;  P0A1P6, GLN1B_SALTY;  
P0A9C8, GLN1B_SHIFL;  P15106, GLN1B_STRCO;  P77958, GLN1B_STRFL;  
Q05542, GLN1B_STRVR;  P28605, GLN1B_SYNP2;  P77961, GLN1B_SYNY3;  
P51120, GLN1B_TRITH;  P19904, GLN1B_VIBAL;  Q9KNJ2, GLN1B_VIBCH;  
O04867, GLNA1_ALNGL;  Q42688, GLNA1_CHLRE;  O22504, GLNA1_DAUCA;  
Q86B00, GLNA1_DICDI;  P20477, GLNA1_DROME;  Q42899, GLNA1_LOTJA;  
P38559, GLNA1_MAIZE;  P04078, GLNA1_MEDSA;  P08282, GLNA1_PEA;  
P04770, GLNA1_PHAVU;  P24099, GLNA1_SOYBN;  P51118, GLNA1_VITVI;  
Q43127, GLNA2_ARATH;  P04772, GLNA2_BRADU;  Q42689, GLNA2_CHLRE;  
O22506, GLNA2_DAUCA;  P0C7B6, GLNA2_DICDI;  P20478, GLNA2_DROME;  
P81643, GLNA2_EMIHU;  P20805, GLNA2_FRAAL;  P13564, GLNA2_HORVU;  
P38560, GLNA2_MAIZE;  Q9XQ94, GLNA2_MEDSA;  P14655, GLNA2_ORYSJ;  
P08281, GLNA2_PEA;  P04771, GLNA2_PHAVU;  P81107, GLNA2_PINPS;  
Q02154, GLNA2_RHILP;  P45626, GLNA2_RHIML;  O82560, GLNA2_SOYBN;  
P22878, GLNA2_STRHY;  P19432, GLNA2_STRVR;  P51119, GLNA2_VITVI;  
P15623, GLNA3_BACFR;  Q05650, GLNA3_BUTFI;  Q54WR9, GLNA3_DICDI;  
Q06378, GLNA3_HORVU;  P14636, GLNA3_LUPAN;  P38561, GLNA3_MAIZE;  
Q43785, GLNA3_MEDSA;  P07694, GLNA3_PEA;  P00965, GLNA3_PHAVU;  
P31592, GLNA3_RHILP;  O87393, GLNA3_RHIME;  P38562, GLNA4_MAIZE;  
Q43066, GLNA4_PEA;  P15102, GLNA4_PHAVU;  P38563, GLNA5_MAIZE;  
Q42624, GLNAC_BRANA;  P25462, GLNAC_MAIZE;  Q9QY94, GLNA_ACOCA;  
O00088, GLNA_AGABI;  Q8X169, GLNA_AMAMU;  Q75BT9, GLNA_ASHGO;  
P15103, GLNA_BOVIN;  P34497, GLNA_CAEEL;  Q6FMT6, GLNA_CANGA;  
Q8HZM5, GLNA_CANLF;  P16580, GLNA_CHICK;  Q12613, GLNA_COLGL;  
P04773, GLNA_CRIGR;  P0CN85, GLNA_CRYNB;  P0CN84, GLNA_CRYNJ;  
Q6B4U7, GLNA_DEBHA;  P11600, GLNA_DUNSA;  Q96V52, GLNA_EMENI;  
Q9UUN6, GLNA_FUSSH;  Q9C2U9, GLNA_GIBFU;  Q96UV5, GLNA_HEBCY;  
P15104, GLNA_HUMAN;  Q874T6, GLNA_KLULA;  P23712, GLNA_LACSA;  
P52782, GLNA_LUPLU;  Q4R7U3, GLNA_MACFA;  Q5UR44, GLNA_MIMIV;  
P15105, GLNA_MOUSE;  Q86ZF9, GLNA_NEUCR;  P12424, GLNA_NICPL;  
Q04831, GLNA_PANAR;  P46410, GLNA_PIG;  P52783, GLNA_PINSY;  
P09606, GLNA_RAT;  Q09179, GLNA_SCHPO;  P41320, GLNA_SQUAC;  
Q8J1R3, GLNA_SUIBO;  P23794, GLNA_SULSO;  Q86ZU6, GLNA_TUBBO;  
P32289, GLNA_VIGAC;  P85087, GLNA_VITSX;  P51121, GLNA_XENLA;  
Q6C3E0, GLNA_YARLI;  P32288, GLNA_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
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