ENZYME entry: EC 6.3.1.8
| Accepted Name |
|---|
| Glutathionylspermidine synthase.
|
| Alternative Name(s) |
|---|
| Gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming). |
| Glutathione:spermidine ligase (ADP-forming). |
| Glutathionylspermidine synthetase. |
| GSP synthetase. |
| Reaction catalysed |
|---|
| Glutathione + spermidine + ATP <=> glutathionylspermidine + ADP + phosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- Involved in the synthesis of trypanothione in trypanosomatids.
- The enzyme from Escherichia coli is bifunctional and also catalyzes
the EC 3.5.1.78 reaction, resulting in a net hydrolysis of ATP.
|
| Cross-references |
|---|
| BRENDA | 6.3.1.8 |
| EC2PDB | 6.3.1.8 |
| ExplorEnz | 6.3.1.8 |
| PRIAM enzyme-specific profiles | 6.3.1.8 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.1.8 |
| IUBMB Enzyme Nomenclature | 6.3.1.8 |
| IntEnz | 6.3.1.8 |
| MEDLINE | Find literature relating to 6.3.1.8 |
| MetaCyc | 6.3.1.8 |
| UniProtKB/Swiss-Prot |
|
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