ID 6.3.1.8 DE glutathionylspermidine synthase. AN gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming). AN glutathione:spermidine ligase (ADP-forming). AN glutathionylspermidine synthetase. AN GSP synthetase. CA ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + CA phosphate. CC -!- Involved in the synthesis of trypanothione in trypanosomatids. CC -!- The enzyme from Escherichia coli is bifunctional and also catalyzes CC the EC 3.5.1.78 reaction, resulting in a net hydrolysis of ATP. DR P90518, GSP_CRIFA ; P0AES0, GSP_ECOLI ; P0AES1, GSP_SHIFL ; //