ENZYME

ENZYME entry: EC 6.3.2.12

Accepted Name

Dihydrofolate synthase.

Alternative Name(s)

7,8-dihydrofolate synthetase.

7,8-dihydropteroate:L-glutamate ligase (ADP).

DHFS.

Dihydrofolate synthetase.

Dihydrofolate synthetase-folylpolyglutamate synthetase.

Dihydropteroate:L-glutamate ligase (ADP-forming).

FHFS.

FHFS/FPGS.

Folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase.

H(2)-folate synthetase.

Reaction catalysed

ATP + 7,8-dihydropteroate + L-glutamate <=> ADP + phosphate + 7,8-dihydropteroylglutamate

Comment(s)

In some bacteria, a single protein catalyzes both this activity and that of EC 6.3.2.17, the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H(4)PteGlu(n)), i.e. various tetrahydrofolates.
In contrast, the activities are located on separate proteins in most eukaryotes studied to date.
This enzyme is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature