ID   6.3.2.14
DE   Enterobactin synthase.
AN   2,3-dihydroxybenzoate--serine ligase.
AN   N-(2,3-dihydroxybenzoyl)-serine synthetase.
CA   6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine = enterobactin + 6 AMP +
CA   6 diphosphate.
CC   -!- This enzyme complex catalyzes the conversion of three molecules each
CC       of 2,3-dihydroxybenzoate and L-serine to form the siderophore
CC       enterobactin.
CC   -!- In Escherichia coli the complex is formed by EntB (an aryl carrier
CC       protein that has to be activated by 4'-phosphopantetheine), EntD (a
CC       phosphopantetheinyl transferase that activates EntB), EntE (catalyzes
CC       the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB
CC       to form the covalently arylated form of EntB), and EntF (a four
CC       domain protein that catalyzes the activation of L-serine by ATP,
CC       the condensation of the activated L-serine with the activated 2,3-
CC       dihydroxybenzoate, and the trimerization of three such moieties to a
CC       single enterobactin molecule).
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