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|Folate polyglutamate synthetase.|
|Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase.|
|Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming).|
|ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate <=> ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)|
- In some bacteria, a single protein catalyzes both this activity and
that of EC 220.127.116.11, the combined activity of which leads to the
formation of the coenzyme polyglutamated tetrahydropteroate
(H(4)PteGlu(n)), i.e. various tetrahydrofolates (H(4)folate).
- In contrast, the activities are located on separate proteins in most
eukaryotes studied to date.
- In Arabidopsis thaliana, this enzyme is present as distinct isoforms
in the mitochondria, the cytosol and the chloroplast.
- Each isoform is encoded by a separate gene, a situation that is
unique among eukaryotes.
- As the affinity of folate-dependent enzymes increases markedly with
the number of glutamic residues, the tetrahydropteroyl polyglutamates
are the preferred coenzymes of C(1) metabolism.
- The enzymes from different sources (particularly eukaryotes versus
prokaryotes) have different substrate specificities with regard to
one-carbon substituents and the number of glutamate residues present
on the tetrahydrofolates.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|Q9HS44, FOLCP_HALSA; ||D4GW05, FOLCP_HALVD; ||Q05865, FOLC_BACSU; |
|A6H751, FOLC_BOVIN; ||P57265, FOLC_BUCAI; ||Q8K9X3, FOLC_BUCAP; |
|Q89AT2, FOLC_BUCBP; ||Q09509, FOLC_CAEEL; ||Q924L9, FOLC_CRIGR; |
|Q54CY5, FOLC_DICDI; ||P08192, FOLC_ECOLI; ||P43775, FOLC_HAEIN; |
|Q05932, FOLC_HUMAN; ||P48760, FOLC_MOUSE; ||I6Y0R5, FOLC_MYCTU; |
|P36001, FOLC_YEAST; ||Q9Y893, FOLE_CANAX; ||O13492, FOLE_NEUCR; |
|O74742, FOLE_SCHPO; ||B3LJR0, FOLE_YEAS1; ||B5VSC3, FOLE_YEAS6; |
|A6ZP80, FOLE_YEAS7; ||C8ZGZ3, FOLE_YEAS8; ||E7KIA3, FOLE_YEASA; |
|E7Q9C7, FOLE_YEASB; ||E7KUJ4, FOLE_YEASL; ||E7NMM0, FOLE_YEASO; |
|Q08645, FOLE_YEAST; ||E7QKX4, FOLE_YEASZ; ||F4K2A1, FPGS1_ARATH; |
|F4J2K2, FPGS2_ARATH; ||Q8W035, FPGS3_ARATH; ||P15925, FPGS_LACCA; |
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