ENZYME entry: EC 6.3.2.2

Accepted Name
Glutamate--cysteine ligase.
Alternative Name(s)
Gamma-glutamyl-L-cysteine synthetase.
Gamma-glutamylcysteine synthetase.
Reaction catalysed
ATP + L-glutamate + L-cysteine <=> ADP + phosphate + gamma-L-glutamyl-L-cysteine
Comment(s)
Can use L-aminohexanoate in place of glutamate.
Cross-references
BRENDA6.3.2.2
EC2PDB6.3.2.2
ExplorEnz6.3.2.2
PRIAM enzyme-specific profiles6.3.2.2
KEGG Ligand Database for Enzyme Nomenclature6.3.2.2
IUBMB Enzyme Nomenclature6.3.2.2
IntEnz6.3.2.2
MEDLINEFind literature relating to 6.3.2.2
MetaCyc6.3.2.2
UniProtKB/Swiss-Prot
A0R5N1, EGTA_MYCS2;  P9WPK6, EGTA_MYCTO;  P9WPK7, EGTA_MYCTU;  
A1R1K8, GCS21_ARTAT;  A0JZ00, GCS21_ARTS2;  Q8FMD3, GCS21_COREF;  
Q0RRF4, GCS21_FRAAA;  Q2JF65, GCS21_FRASC;  Q5X7D7, GCS21_LEGPA;  
A5IAK4, GCS21_LEGPC;  Q5WYT4, GCS21_LEGPL;  A0QQQ2, GCS21_MYCS2;  
A3PTZ8, GCS21_MYCSJ;  A1UAE3, GCS21_MYCSK;  A1T324, GCS21_MYCVP;  
Q5YW64, GCS21_NOCFA;  A1SKY7, GCS21_NOCSJ;  Q0SH75, GCS21_RHOJR;  
Q1B017, GCS21_RUBXD;  A4FDR2, GCS21_SACEN;  Q82PX1, GCS21_STRAW;  
A1R8M8, GCS22_ARTAT;  A0K1R7, GCS22_ARTS2;  Q8FT06, GCS22_COREF;  
Q0RKL9, GCS22_FRAAA;  Q2J8X3, GCS22_FRASC;  Q5X1G7, GCS22_LEGPA;  
A5IGU3, GCS22_LEGPC;  Q5WT78, GCS22_LEGPL;  A0QXJ6, GCS22_MYCS2;  
A3Q5U2, GCS22_MYCSJ;  A1ULE3, GCS22_MYCSK;  A1TEV2, GCS22_MYCVP;  
Q5YNU2, GCS22_NOCFA;  A1SLX8, GCS22_NOCSJ;  Q0SEQ7, GCS22_RHOJR;  
Q1AWY5, GCS22_RUBXD;  A4FHB5, GCS22_SACEN;  Q82PC4, GCS22_STRAW;  
A1RAU1, GCS23_ARTAT;  Q0RHA0, GCS23_FRAAA;  A0R3T8, GCS23_MYCS2;  
A1SN17, GCS23_NOCSJ;  Q0S8V5, GCS23_RHOJR;  Q1AWB5, GCS23_RUBXD;  
Q0RZ64, GCS24_RHOJR;  A1TJA3, GCS2_ACIAC;  B9MBR0, GCS2_ACIET;  
A1W2Y5, GCS2_ACISJ;  Q3M5M3, GCS2_ANAVT;  A8I5N7, GCS2_AZOC5;  
A1K7T8, GCS2_AZOSB;  Q6MKW4, GCS2_BDEBA;  Q2L0C4, GCS2_BORA1;  
Q7WQP1, GCS2_BORBR;  Q7W1R5, GCS2_BORPA;  A9IFL0, GCS2_BORPD;  
Q7VS51, GCS2_BORPE;  Q89NS0, GCS2_BRADU;  A5ESE1, GCS2_BRASB;  
A4YLK4, GCS2_BRASO;  B1YQ56, GCS2_BURA4;  Q1BZN8, GCS2_BURCA;  
B1K1H9, GCS2_BURCC;  A0K2U6, GCS2_BURCH;  B4E558, GCS2_BURCJ;  
Q0BJQ3, GCS2_BURCM;  Q39L14, GCS2_BURL3;  A9AJC7, GCS2_BURM1;  
A3MQF9, GCS2_BURM7;  A2S6N7, GCS2_BURM9;  Q62FV3, GCS2_BURMA;  
A1V8X0, GCS2_BURMS;  A3NPL5, GCS2_BURP0;  Q3JXS3, GCS2_BURP1;  
A3N3Y5, GCS2_BURP6;  Q63Z36, GCS2_BURPS;  Q2T2K3, GCS2_BURTA;  
A4J9Z8, GCS2_BURVG;  Q13SL4, GCS2_BURXL;  A9WAH5, GCS2_CHLAA;  
B8GCV1, GCS2_CHLAD;  B9LEN6, GCS2_CHLSY;  Q7NTZ9, GCS2_CHRVO;  
A8AJN1, GCS2_CITK8;  A5CQQ7, GCS2_CLAM3;  B0REM7, GCS2_CLAMS;  
Q6NF59, GCS2_CORDI;  A4QHD8, GCS2_CORGB;  Q8NM44, GCS2_CORGL;  
Q4JXP1, GCS2_CORJK;  B1VHM9, GCS2_CORU7;  A7MNP0, GCS2_CROS8;  
Q1LHL9, GCS2_CUPMC;  Q0K5N7, GCS2_CUPNH;  Q46VZ0, GCS2_CUPPJ;  
B3R7K5, GCS2_CUPTR;  Q47E74, GCS2_DECAR;  A8LME6, GCS2_DINSH;  
A7ZIW5, GCS2_ECO24;  B7UKM3, GCS2_ECO27;  B7MEZ2, GCS2_ECO45;  
B7L8G3, GCS2_ECO55;  Q8XBX1, GCS2_ECO57;  B5YPS4, GCS2_ECO5E;  
B7NLU0, GCS2_ECO7I;  B7MRL6, GCS2_ECO81;  B7M4R1, GCS2_ECO8A;  
C4ZV25, GCS2_ECOBW;  A7ZXK4, GCS2_ECOHS;  A1A8L2, GCS2_ECOK1;  
Q0TK91, GCS2_ECOL5;  Q8FK30, GCS2_ECOL6;  B1IYM7, GCS2_ECOLC;  
P77213, GCS2_ECOLI;  B7N9I5, GCS2_ECOLU;  B6I0N0, GCS2_ECOSE;  
B1LKH2, GCS2_ECOSM;  Q1REY3, GCS2_ECOUT;  A4W7T6, GCS2_ENT38;  
B7LLN2, GCS2_ESCF3;  Q7NI89, GCS2_GLOVI;  B9LMG2, GCS2_HALLT;  
Q5V3Q5, GCS2_HALMA;  B0R5I4, GCS2_HALS3;  Q9HPZ9, GCS2_HALSA;  
D4GZN2, GCS2_HALVD;  Q18H65, GCS2_HALWD;  A9B2Z8, GCS2_HERA2;  
A4G807, GCS2_HERAR;  A6T1A0, GCS2_JANMA;  Q28R34, GCS2_JANSC;  
B5Y035, GCS2_KLEP3;  A6T5Z2, GCS2_KLEP7;  C1DD64, GCS2_LARHH;  
Q5ZS01, GCS2_LEGPH;  Q6AE97, GCS2_LEIXX;  B1Y1M1, GCS2_LEPCP;  
A2SKM7, GCS2_METPP;  C5CC09, GCS2_MICLC;  A0QLR0, GCS2_MYCA1;  
P64694, GCS2_MYCBO;  A1KFQ5, GCS2_MYCBP;  C1AKA9, GCS2_MYCBT;  
Q73T00, GCS2_MYCPA;  Q1BEJ0, GCS2_MYCSS;  A5TZF9, GCS2_MYCTA;  
P9WPK8, GCS2_MYCTO;  P9WPK9, GCS2_MYCTU;  A0PNK6, GCS2_MYCUA;  
Q3IQ21, GCS2_NATPD;  Q2Y8S0, GCS2_NITMU;  A1B2I7, GCS2_PARDP;  
B2T7N6, GCS2_PARPJ;  A1VTI2, GCS2_POLNA;  Q123D5, GCS2_POLSJ;  
A6V5Z4, GCS2_PSEA7;  B7V9S6, GCS2_PSEA8;  Q02LX5, GCS2_PSEAB;  
Q9I1T4, GCS2_PSEAE;  Q1I926, GCS2_PSEE4;  Q4K7H5, GCS2_PSEF5;  
A4XUP3, GCS2_PSEMY;  Q88HV0, GCS2_PSEPK;  B2UG86, GCS2_RALPJ;  
Q8XU95, GCS2_RALSO;  Q7USI0, GCS2_RHOBA;  Q2RRI3, GCS2_RHORT;  
A7NK74, GCS2_ROSCS;  A5UWI8, GCS2_ROSS1;  Q5LRC0, GCS2_RUEPO;  
B5EYH4, GCS2_SALA4;  A8M5J6, GCS2_SALAI;  A9ML47, GCS2_SALAR;  
Q57RZ1, GCS2_SALCH;  B5FMI4, GCS2_SALDC;  B5QUY5, GCS2_SALEP;  
B5R705, GCS2_SALG2;  B4TAD4, GCS2_SALHS;  B4SXT5, GCS2_SALNS;  
Q5PMF1, GCS2_SALPA;  A9MVD3, GCS2_SALPB;  C0PVN0, GCS2_SALPC;  
B5BCW8, GCS2_SALPK;  B4TP54, GCS2_SALSV;  Q8Z8M0, GCS2_SALTI;  
A4X7Y6, GCS2_SALTO;  Q8ZR41, GCS2_SALTY;  Q324W2, GCS2_SHIBS;  
Q32J06, GCS2_SHIDS;  Q0T746, GCS2_SHIF8;  Q83M14, GCS2_SHIFL;  
Q3Z4L2, GCS2_SHISS;  Q01ZM2, GCS2_SOLUE;  A9GS95, GCS2_SORC5;  
Q9KY07, GCS2_STRCO;  Q47LS4, GCS2_THEFY;  A1WFG0, GCS2_VEREI;  
Q8GU95, GSH1A_ORYSI;  Q688Q9, GSH1A_ORYSJ;  A2YL07, GSH1B_ORYSI;  
Q6Z3A3, GSH1B_ORYSJ;  Q0VSY7, GSH1_ALCBS;  B6EGB3, GSH1_ALISL;  
P46309, GSH1_ARATH;  C1DJH1, GSH1_AZOVD;  Q1LTQ6, GSH1_BAUCH;  
Q7WES2, GSH1_BORBR;  Q7W3F2, GSH1_BORPA;  A9HYE0, GSH1_BORPD;  
O23736, GSH1_BRAJU;  B8D9I8, GSH1_BUCA5;  P57485, GSH1_BUCAI;  
P58994, GSH1_BUCAP;  B8D7U0, GSH1_BUCAT;  Q89AD8, GSH1_BUCBP;  
Q20117, GSH1_CAEEL;  Q9HF78, GSH1_CANAX;  A8ANP6, GSH1_CITK8;  
Q97IV1, GSH1_CLOAB;  A7MJ27, GSH1_CROS8;  Q54PC2, GSH1_DICDI;  
Q9W3K5, GSH1_DROME;  A7ZQC1, GSH1_ECO24;  B7UHB1, GSH1_ECO27;  
B7MKG2, GSH1_ECO45;  B7LEA4, GSH1_ECO55;  Q8X900, GSH1_ECO57;  
B5Z2A3, GSH1_ECO5E;  B7NSH3, GSH1_ECO7I;  B7MYJ3, GSH1_ECO81;  
B7M9D0, GSH1_ECO8A;  C4ZYT8, GSH1_ECOBW;  B1XCM1, GSH1_ECODH;  
A8A3H0, GSH1_ECOHS;  Q0TEI7, GSH1_ECOL5;  P0A6X0, GSH1_ECOL6;  
B1IUY6, GSH1_ECOLC;  P0A6W9, GSH1_ECOLI;  B7N6S3, GSH1_ECOLU;  
B6I679, GSH1_ECOSE;  B1LPG3, GSH1_ECOSM;  Q1R808, GSH1_ECOUT;  
C5BGG7, GSH1_EDWI9;  A4WDQ2, GSH1_ENT38;  B2VHD0, GSH1_ERWT9;  
B7LVZ1, GSH1_ESCF3;  Q2S8F7, GSH1_HAHCH;  P48506, GSH1_HUMAN;  
A6SX59, GSH1_JANMA;  B5XVC3, GSH1_KLEP3;  A6TCV4, GSH1_KLEP7;  
Q72RD4, GSH1_LEPIC;  Q8F4D5, GSH1_LEPIN;  Q9ZNX6, GSH1_MEDTR;  
P97494, GSH1_MOUSE;  Q8X0X0, GSH1_NEUCR;  Q9NFN6, GSH1_ONCVO;  
Q6D1T4, GSH1_PECAS;  C6DCQ5, GSH1_PECCP;  Q7N7A4, GSH1_PHOLL;  
Q6LMV1, GSH1_PHOPR;  B4EUV9, GSH1_PROMH;  Q48PX1, GSH1_PSE14;  
A6VDX9, GSH1_PSEA7;  B7V3V0, GSH1_PSEA8;  Q02EG1, GSH1_PSEAB;  
Q9HTY6, GSH1_PSEAE;  Q1IGL1, GSH1_PSEE4;  Q4KK14, GSH1_PSEF5;  
Q3IEB7, GSH1_PSEHT;  A4XP63, GSH1_PSEMY;  Q3KJQ5, GSH1_PSEPF;  
Q88R90, GSH1_PSEPK;  B1JET4, GSH1_PSEPW;  Q88AR1, GSH1_PSESM;  
P61379, GSH1_PSESY;  Q4ZZU4, GSH1_PSEU2;  A4VG81, GSH1_PSEU5;  
P19468, GSH1_RAT;  Q21EP1, GSH1_SACD2;  B5F346, GSH1_SALA4;  
A9MFZ5, GSH1_SALAR;  Q57KV3, GSH1_SALCH;  B5FSX4, GSH1_SALDC;  
B5QV72, GSH1_SALEP;  B5RDE8, GSH1_SALG2;  B4TF06, GSH1_SALHS;  
B4T394, GSH1_SALNS;  Q5PF10, GSH1_SALPA;  A9N0B5, GSH1_SALPB;  
C0PWL7, GSH1_SALPC;  B5BEN1, GSH1_SALPK;  B4TT00, GSH1_SALSV;  
Q8Z4D6, GSH1_SALTI;  O68838, GSH1_SALTY;  Q09768, GSH1_SCHPO;  
A8GA13, GSH1_SERP5;  A1S4F9, GSH1_SHEAM;  B0TK23, GSH1_SHEHH;  
Q8EBF9, GSH1_SHEON;  A8H1U8, GSH1_SHEPA;  B2U053, GSH1_SHIB3;  
Q31X58, GSH1_SHIBS;  Q32CN5, GSH1_SHIDS;  Q0T1B9, GSH1_SHIF8;  
Q3YYH0, GSH1_SHISS;  Q2NVK9, GSH1_SODGM;  O22493, GSH1_SOLLC;  
Q1W2L8, GSH1_TOBAC;  A7MZY1, GSH1_VIBCB;  Q9KUG5, GSH1_VIBCH;  
Q5E7F8, GSH1_VIBF1;  B5FAD9, GSH1_VIBFM;  Q87LS2, GSH1_VIBPA;  
Q8DC38, GSH1_VIBVU;  Q7MHS5, GSH1_VIBVY;  Q8D2V5, GSH1_WIGBR;  
P32477, GSH1_YEAST;  A1JK14, GSH1_YERE8;  Q8ZBU2, GSH1_YERPE;  
Q66E64, GSH1_YERPS;  Q8XK30, GSHAB_CLOPE;  Q6ANW2, GSHAB_DESPS;  
Q82ZG8, GSHAB_ENTFA;  Q88UW5, GSHAB_LACPL;  Q926X7, GSHAB_LISIN;  
Q71VZ1, GSHAB_LISMF;  Q8Y3R3, GSHAB_LISMO;  A0AMA3, GSHAB_LISW6;  
Q65RX0, GSHAB_MANSM;  Q9CM00, GSHAB_PASMU;  Q8E399, GSHAB_STRA3;  
Q8DXM9, GSHAB_STRA5;  Q8DW15, GSHAB_STRMU;  Q5LYY5, GSHAB_STRT1;  
Q5M3J8, GSHAB_STRT2;  

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