ENZYME entry: EC 6.3.2.26
| Accepted Name |
|---|
| N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase.
|
| Alternative Name(s) |
|---|
| ACV synthetase. |
| L-alpha-aminoadipyl-cysteinyl-valine synthetase. |
| L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase. |
| Reaction catalysed |
|---|
| L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H(2)O <=> N-(L-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- The enzyme contains 4'-phosphopantetheine, which may be involved in
the mechanism of the reaction.
- Forms part of the penicillin biosynthesis pathway.
|
| Cross-references |
|---|
| PROSITE | PDOC00427 |
| BRENDA | 6.3.2.26 |
| EC2PDB | 6.3.2.26 |
| ExplorEnz | 6.3.2.26 |
| PRIAM enzyme-specific profiles | 6.3.2.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.26 |
| IUBMB Enzyme Nomenclature | 6.3.2.26 |
| IntEnz | 6.3.2.26 |
| MEDLINE | Find literature relating to 6.3.2.26 |
| MetaCyc | 6.3.2.26 |
| UniProtKB/Swiss-Prot |
|
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