ENZYME entry: EC 6.3.2.35

Accepted Name
D-alanine--D-serine ligase.
Reaction catalysed
D-alanine + D-serine + ATP <=> D-alanyl-D-serine + ADP + phosphate
Comment(s)
  • The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D- alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine--D- alanine ligase.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cross-references
BRENDA6.3.2.35
EC2PDB6.3.2.35
ExplorEnz6.3.2.35
PRIAM enzyme-specific profiles6.3.2.35
KEGG Ligand Database for Enzyme Nomenclature6.3.2.35
IUBMB Enzyme Nomenclature6.3.2.35
IntEnz6.3.2.35
MEDLINEFind literature relating to 6.3.2.35
MetaCyc6.3.2.35

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-