ENZYME entry: EC 6.3.2.36
| Accepted Name |
|---|
| 4-phosphopantoate--beta-alanine ligase.
|
| Alternative Name(s) |
|---|
| Phosphopantothenate synthetase. |
| Reaction catalysed |
|---|
| ATP + (R)-4-phosphopantoate + beta-alanine <=> AMP + diphosphate + (R)-4'-phosphopantothenate |
| Comment(s) |
|---|
- The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part
of the pathway leading to biosynthesis of 4'-phosphopantetheine,
an essential cofactor of coenzyme A and acyl-carrier protein.
- In bacteria and eukaryotes this conversion is performed by
condensation with beta-alanine, followed by phosphorylation
(EC 6.3.2.1 and EC 2.7.1.33, respectively).
- In archaea the order of these two steps is reversed,
and phosphorylation precedes condensation with beta-alanine.
- The two archaeal enzymes that catalyze this conversion are
EC 2.7.1.169 and this enzyme.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.36 |
| EC2PDB | 6.3.2.36 |
| ExplorEnz | 6.3.2.36 |
| PRIAM enzyme-specific profiles | 6.3.2.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.36 |
| IUBMB Enzyme Nomenclature | 6.3.2.36 |
| IntEnz | 6.3.2.36 |
| MEDLINE | Find literature relating to 6.3.2.36 |
| MetaCyc | 6.3.2.36 |
| UniProtKB/Swiss-Prot |
|
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