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ENZYME entry: EC

Accepted Name
4-phosphopantoate--beta-alanine ligase.
Alternative Name(s)
Phosphopantothenate synthetase.
Reaction catalysed
ATP + (R)-4-phosphopantoate + beta-alanine <=> AMP + diphosphate + (R)-4'-phosphopantothenate
  • The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein.
  • In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC and EC, respectively).
  • In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
  • The two archaeal enzymes that catalyze this conversion are EC and this enzyme.
PRIAM enzyme-specific profiles6.3.2.36
KEGG Ligand Database for Enzyme Nomenclature6.3.2.36
IUBMB Enzyme Nomenclature6.3.2.36
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