ID 6.3.2.36 DE 4-phosphopantoate--beta-alanine ligase. AN phosphopantothenate synthetase. CA (R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + CA AMP + diphosphate + H(+). CC -!- The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part CC of the pathway leading to biosynthesis of 4'-phosphopantetheine, CC an essential cofactor of coenzyme A and acyl-carrier protein. CC -!- In bacteria and eukaryotes this conversion is performed by CC condensation with beta-alanine, followed by phosphorylation CC (EC 6.3.2.1 and EC 2.7.1.33, respectively). CC -!- In archaea the order of these two steps is reversed, CC and phosphorylation precedes condensation with beta-alanine. CC -!- The two archaeal enzymes that catalyze this conversion are CC EC 2.7.1.169 and this enzyme. DR Q2FUA9, PPS_METHJ ; Q57662, PPS_METJA ; Q8PUQ1, PPS_METMA ; DR Q5JIZ8, PPS_THEKO ; B6YXQ1, PPS_THEON ; //