ENZYME entry: EC 6.3.2.38

Accepted Name
N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase.
Alternative Name(s)
N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase.
Reaction catalysed
2 ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine + H(2)O <=> 2 ADP + 2 phosphate + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine
Cofactor(s)
Mg(2+).
Comment(s)
  • Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation.
  • It is a dihydroxamate comprising two molecules of N(6)-acetyl-N(6)- hydroxy-L-lysine and one molecule of citrate.
  • This enzyme catalyzes the first of two synthase reactions to link N(6)-acetyl-N(6)-hydroxy-L-lysine and citrate.
  • Formerly EC 6.3.2.27.
Cross-references
BRENDA6.3.2.38
EC2PDB6.3.2.38
ExplorEnz6.3.2.38
PRIAM enzyme-specific profiles6.3.2.38
KEGG Ligand Database for Enzyme Nomenclature6.3.2.38
IUBMB Enzyme Nomenclature6.3.2.38
IntEnz6.3.2.38
MEDLINEFind literature relating to 6.3.2.38
MetaCyc6.3.2.38
UniProtKB/Swiss-Prot
Q47316, IUCA_ECOLX;  Q76BS7, IUCA_VIBMI;  

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