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ENZYME entry: EC

Accepted Name
[Lysine-biosynthesis-protein LysW]--L-2-aminoadipate ligase.
Alternative Name(s)
AAA--LysW ligase.
Alpha-aminoadipate-lysW ligase.
Reaction catalysed
ATP + [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [lysine-biosynthesis-protein LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate
  • The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW.
  • This reaction is part of the lysine biosynthesis pathway in these organisms.
  • Formerly EC 6.3.2.n4.
PRIAM enzyme-specific profiles6.3.2.43
KEGG Ligand Database for Enzyme Nomenclature6.3.2.43
IUBMB Enzyme Nomenclature6.3.2.43
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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-