ENZYME entry: EC 6.3.2.43

Accepted Name
[Lysine-biosynthesis-protein LysW]--L-2-aminoadipate ligase.
Alternative Name(s)
AAA--LysW ligase.
Alpha-aminoadipate-lysW ligase.
Reaction catalysed
ATP + [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [lysine-biosynthesis-protein LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate
Comment(s)
  • The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW.
  • This reaction is part of the lysine biosynthesis pathway in these organisms.
  • Formerly EC 6.3.2.n4.
Cross-references
BRENDA6.3.2.43
EC2PDB6.3.2.43
ExplorEnz6.3.2.43
PRIAM enzyme-specific profiles6.3.2.43
KEGG Ligand Database for Enzyme Nomenclature6.3.2.43
IUBMB Enzyme Nomenclature6.3.2.43
IntEnz6.3.2.43
MEDLINEFind literature relating to 6.3.2.43
MetaCyc6.3.2.43
UniProtKB/Swiss-Prot
Q4JAP9, LYSX_SULAC;  Q7SI95, LYSX_SULSO;  Q976J9, LYSX_SULTO;  
Q5SH23, LYSX_THET8;  

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