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ENZYME entry: EC

Accepted Name
UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase.
Alternative Name(s)
Murein peptide ligase.
Reaction catalysed
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
  • The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division.
  • The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro.
PRIAM enzyme-specific profiles6.3.2.45
KEGG Ligand Database for Enzyme Nomenclature6.3.2.45
IUBMB Enzyme Nomenclature6.3.2.45
MEDLINEFind literature relating to
P37773, MPL_ECOLI;  P43948, MPL_HAEIN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-