ENZYME entry: EC 6.3.2.47

Accepted Name
Dapdiamide synthase.
Alternative Name(s)
Dapdiamide A synthase.
Reaction catalysed
  • ATP + 3-((((2R,3R)-3-carboxyoxiran-2-yl)carbonyl)amino)-L-alanine + L-valine <=> ADP + phosphate + 3-((((2R,3R)-3-carboxyoxiran-2-yl)carbonyl)amino)-L-alanyl-L-valine
  • ATP + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-valine <=> ADP + phosphate + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanyl-L-valine
  • ATP + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-isoleucine <=> ADP + phosphate + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanyl-L-isoleucine
  • ATP + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanine + L-leucine <=> ADP + phosphate + 3-(((2E)-4-amino-4-oxobut-2-enoyl)amino)-L-alanyl-L-leucine
Comment(s)
The enzyme, characterized from the bacterium Pantoea agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold.
Cross-references
BRENDA6.3.2.47
EC2PDB6.3.2.47
ExplorEnz6.3.2.47
PRIAM enzyme-specific profiles6.3.2.47
KEGG Ligand Database for Enzyme Nomenclature6.3.2.47
IUBMB Enzyme Nomenclature6.3.2.47
IntEnz6.3.2.47
MEDLINEFind literature relating to 6.3.2.47
MetaCyc6.3.2.47
UniProtKB/Swiss-Prot
E2JA31, DDAF_ENTAG

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