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ENZYME

ENZYME entry: EC 6.3.2.47

Accepted Name
dapdiamide synthase
Alternative Name(s)
dapdiamide A synthase
Reaction catalysed
  • 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate
  • ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate
  • ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate
  • ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate
Comment(s)
The enzyme, characterized from the bacterium Pantoea agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold.
Cross-references
BRENDA6.3.2.47
EC2PDB6.3.2.47
ExplorEnz6.3.2.47
PRIAM enzyme-specific profiles6.3.2.47
KEGG Ligand Database for Enzyme Nomenclature6.3.2.47
IUBMB Enzyme Nomenclature6.3.2.47
IntEnz6.3.2.47
MEDLINEFind literature relating to 6.3.2.47
MetaCyc6.3.2.47
Rhea expert-curated reactions6.3.2.47
UniProtKB/Swiss-Prot
E2JA31, DDAF_ENTAG

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