ENZYME entry: EC 6.3.2.7

Accepted Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
Alternative Name(s)
L-lysine-adding enzyme.
MurE synthetase.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase.
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase.
Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase.
Reaction catalysed
ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine <=> ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
Comment(s)
  • Involved with EC 6.3.2.4, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.
  • This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
Cross-references
BRENDA6.3.2.7
EC2PDB6.3.2.7
ExplorEnz6.3.2.7
PRIAM enzyme-specific profiles6.3.2.7
KEGG Ligand Database for Enzyme Nomenclature6.3.2.7
IUBMB Enzyme Nomenclature6.3.2.7
IntEnz6.3.2.7
MEDLINEFind literature relating to 6.3.2.7
MetaCyc6.3.2.7
UniProtKB/Swiss-Prot
Q838A4, MURE_ENTFA;  A7X0P6, MURE_STAA1;  Q2FI59, MURE_STAA3;  
Q2FZP6, MURE_STAA8;  Q2YWY9, MURE_STAAB;  O86491, MURE_STAAC;  
P65479, MURE_STAAM;  P65480, MURE_STAAN;  Q6GI66, MURE_STAAR;  
Q6GAQ9, MURE_STAAS;  Q8NXC2, MURE_STAAW;  Q5HQE6, MURE_STAEQ;  
Q8CPR2, MURE_STAES;  Q4L525, MURE_STAHJ;  Q3K0C1, MURE_STRA1;  
Q8E4E0, MURE_STRA3;  Q8DYT2, MURE_STRA5;  Q8DST2, MURE_STRMU;  
Q9A196, MURE_STRP1;  Q04JL8, MURE_STRP2;  P0DC54, MURE_STRP3;  
Q5XDM7, MURE_STRP6;  Q8P2B4, MURE_STRP8;  Q1JN87, MURE_STRPC;  
Q1JID8, MURE_STRPD;  Q1J890, MURE_STRPF;  A2RG75, MURE_STRPG;  
Q48V28, MURE_STRPM;  Q97PS1, MURE_STRPN;  P0DC55, MURE_STRPQ;  
Q8CWQ5, MURE_STRR6;  A4W0C1, MURE_STRS2;  A3CPL6, MURE_STRSV;  
A4VU28, MURE_STRSY;  Q5M1B4, MURE_STRT1;  Q5M5V0, MURE_STRT2;  
Q03M85, MURE_STRTD;  Q9WY79, MURE_THEMA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
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