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ENZYME entry: EC 6.3.3.4

Accepted Name
(Carboxyethyl)arginine beta-lactam-synthase.
Alternative Name(s)
Beta-lactam synthetase.
Reaction catalysed
ATP + L-N(2)-(2-carboxyethyl)arginine <=> AMP + diphosphate + deoxyamidinoproclavaminate
Comment(s)
  • Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
  • It has been proposed that L-N(2)-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.
Cross-references
BRENDA6.3.3.4
EC2PDB6.3.3.4
ExplorEnz6.3.3.4
PRIAM enzyme-specific profiles6.3.3.4
KEGG Ligand Database for Enzyme Nomenclature6.3.3.4
IUBMB Enzyme Nomenclature6.3.3.4
IntEnz6.3.3.4
MEDLINEFind literature relating to 6.3.3.4
MetaCyc6.3.3.4
UniProtKB/Swiss-Prot
P0DJQ8, BLS_STRC2;  P0DJQ7, BLS_STRCL;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.3.-
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