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ENZYME

ENZYME entry: EC 6.3.3.4

PURL: https://purl.expasy.org/enzyme/EC/6.3.3.4
Accepted Name
(carboxyethyl)arginine beta-lactam-synthase
Alternative Name(s)
beta-lactam synthetase
Reaction catalysed
N(2)-(2-carboxyethyl)-L-arginine + ATP = deoxyamidinoproclavaminate + AMP + diphosphate + H(+)
Comment(s)
  • Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
  • It has been proposed that L-N(2)-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.
Cross-references
BRENDA6.3.3.4
EC2PDB6.3.3.4
ExplorEnz6.3.3.4
KEGG Ligand Database for Enzyme Nomenclature6.3.3.4
IUBMB Enzyme Nomenclature6.3.3.4
MEDLINEFind literature relating to 6.3.3.4
MetaCyc6.3.3.4
Rhea expert-curated reactions6.3.3.4
UniProtKB/Swiss-Prot
P0DJQ7, BLS_STRCL

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