ENZYME entry: EC 6.3.4.21

Accepted Name
Nicotinate phosphoribosyltransferase.
Alternative Name(s)
Niacin ribonucleotidase.
Nicotinic acid mononucleotide glycohydrolase.
Nicotinic acid mononucleotide pyrophosphorylase.
Nicotinic acid phosphoribosyltransferase.
Reaction catalysed
Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O <=> beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
Comment(s)
  • The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP.
  • However, when ATP is available the enzyme is phosphorylated resulting in a much lower K(m) for nicotinate.
  • The phospho-enzyme is hydrolyzed during the transferase reaction, regenerating the low affinity form.
  • The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100.
  • Formerly EC 2.4.2.11.
Cross-references
BRENDA6.3.4.21
EC2PDB6.3.4.21
ExplorEnz6.3.4.21
PRIAM enzyme-specific profiles6.3.4.21
KEGG Ligand Database for Enzyme Nomenclature6.3.4.21
IUBMB Enzyme Nomenclature6.3.4.21
IntEnz6.3.4.21
MEDLINEFind literature relating to 6.3.4.21
MetaCyc6.3.4.21
UniProtKB/Swiss-Prot
Q8RWM2, NPRT1_ARATH;  Q84WV8, NPRT2_ARATH;  Q9UTK3, NPT1_SCHPO;  
P39683, NPT1_YEAST;  P9WJI8, PNCB1_MYCTO;  P9WJI9, PNCB1_MYCTU;  
Q9HUP4, PNCB1_PSEAE;  P9WJI6, PNCB2_MYCTO;  P9WJI7, PNCB2_MYCTU;  
Q9HW26, PNCB2_PSEAE;  Q6F6W1, PNCB_ACIAD;  B2I1P1, PNCB_ACIBC;  
A3MA25, PNCB_ACIBT;  B9MHC7, PNCB_ACIET;  A1W8S8, PNCB_ACISJ;  
Q8UIS9, PNCB_AGRFC;  B9J6S5, PNCB_AGRRK;  B9JYR4, PNCB_AGRVS;  
O32090, PNCB_BACSU;  A1UUA2, PNCB_BARBK;  Q6G5H6, PNCB_BARHE;  
Q6G0X7, PNCB_BARQU;  A9ILN1, PNCB_BART1;  Q7WCZ8, PNCB_BORBR;  
Q7W5G3, PNCB_BORPA;  A9IIC5, PNCB_BORPD;  Q7VTF7, PNCB_BORPE;  
A5PK51, PNCB_BOVIN;  Q89SS3, PNCB_BRADU;  A5E8V7, PNCB_BRASB;  
A4YK54, PNCB_BRASO;  B2S8A9, PNCB_BRUA1;  Q2YNV6, PNCB_BRUA2;  
Q57FQ9, PNCB_BRUAB;  A9M757, PNCB_BRUC2;  C0RGH3, PNCB_BRUMB;  
Q8YEP2, PNCB_BRUME;  B0CIM5, PNCB_BRUSI;  Q8G340, PNCB_BRUSU;  
B8D9E6, PNCB_BUCA5;  P57442, PNCB_BUCAI;  Q8K9I6, PNCB_BUCAP;  
B8D7P8, PNCB_BUCAT;  B1YVJ0, PNCB_BURA4;  Q1BXX4, PNCB_BURCA;  
B1JY80, PNCB_BURCC;  A0K5S6, PNCB_BURCH;  Q0BH38, PNCB_BURCM;  
Q62LW1, PNCB_BURMA;  Q63S63, PNCB_BURPS;  A4JCM8, PNCB_BURVG;  
Q95XX1, PNCB_CAEEL;  Q11HJ2, PNCB_CHESB;  Q1QZ10, PNCB_CHRSD;  
Q7NSK2, PNCB_CHRVO;  A8AIE5, PNCB_CITK8;  A7MEW8, PNCB_CROS8;  
Q0K8J9, PNCB_CUPNH;  Q6P3H4, PNCB_DANRE;  C0QFM5, PNCB_DESAH;  
Q55G10, PNCB_DICDI;  Q9VQX4, PNCB_DROME;  A7ZK22, PNCB_ECO24;  
B7UN17, PNCB_ECO27;  B7MHP0, PNCB_ECO45;  B7LE31, PNCB_ECO55;  
Q8XDE8, PNCB_ECO57;  B5YT65, PNCB_ECO5E;  B7NM43, PNCB_ECO7I;  
B7MS49, PNCB_ECO81;  B7M860, PNCB_ECO8A;  C4ZQ57, PNCB_ECOBW;  
B1X8N5, PNCB_ECODH;  A7ZYN4, PNCB_ECOHS;  Q8FJ98, PNCB_ECOL6;  
P18133, PNCB_ECOLI;  B7N398, PNCB_ECOLU;  B6I904, PNCB_ECOSE;  
B1LJT2, PNCB_ECOSM;  C5BD56, PNCB_EDWI9;  A4W8V0, PNCB_ENT38;  
B2VC92, PNCB_ERWT9;  B7LNU8, PNCB_ESCF3;  A4G168, PNCB_HERAR;  
Q6XQN6, PNCB_HUMAN;  Q8TMW6, PNCB_METAC;  Q12Z05, PNCB_METBU;  
Q8PSJ3, PNCB_METMA;  Q8CC86, PNCB_MOUSE;  Q5F836, PNCB_NEIG1;  
B4RL23, PNCB_NEIG2;  A9M0T9, PNCB_NEIM0;  Q9JTM8, PNCB_NEIMA;  
Q9JYM9, PNCB_NEIMB;  Q1QI14, PNCB_NITHX;  A6WV52, PNCB_OCHA4;  
Q6D454, PNCB_PECAS;  C6DFB8, PNCB_PECCP;  Q7N621, PNCB_PHOLL;  
Q6LRA6, PNCB_PHOPR;  Q128P8, PNCB_POLSJ;  B4EVC0, PNCB_PROMH;  
Q48NY1, PNCB_PSE14;  A4XS60, PNCB_PSEMY;  A5W9Q6, PNCB_PSEP1;  
Q3KIW4, PNCB_PSEPF;  B0KKX3, PNCB_PSEPG;  Q88DF7, PNCB_PSEPK;  
Q87VL5, PNCB_PSESM;  Q4ZYV7, PNCB_PSEU2;  A1SVJ9, PNCB_PSYIN;  
B2U8V2, PNCB_RALPJ;  Q8Y0L2, PNCB_RALSO;  Q6XQN1, PNCB_RAT;  
B3PXL5, PNCB_RHIE6;  Q2KDT0, PNCB_RHIEC;  Q98D24, PNCB_RHILO;  
B5ZWU4, PNCB_RHILW;  Q92S49, PNCB_RHIME;  C3MFW1, PNCB_RHISN;  
B5F1U0, PNCB_SALA4;  A9MHU8, PNCB_SALAR;  Q57QZ3, PNCB_SALCH;  
B5FQ81, PNCB_SALDC;  B5QZD8, PNCB_SALEP;  B5R8M1, PNCB_SALG2;  
B4TDS5, PNCB_SALHS;  B4T172, PNCB_SALNS;  Q5PGD8, PNCB_SALPA;  
A9N6Y6, PNCB_SALPB;  C0PXX2, PNCB_SALPC;  B5BBM4, PNCB_SALPK;  
B4TRW6, PNCB_SALSV;  Q8Z7Y9, PNCB_SALTI;  P22253, PNCB_SALTY;  
A8GCJ6, PNCB_SERP5;  B2TUE4, PNCB_SHIB3;  Q31YR6, PNCB_SHIBS;  
Q32E52, PNCB_SHIDS;  Q83LN3, PNCB_SHIFL;  Q3Z3I9, PNCB_SHISS;  
A6U5X9, PNCB_SINMW;  Q2NU84, PNCB_SODGM;  Q9HJ28, PNCB_THEAC;  
A1WJL0, PNCB_VEREI;  A5F1F1, PNCB_VIBC3;  A7N4I5, PNCB_VIBCB;  
Q9KN67, PNCB_VIBCH;  C3LUC2, PNCB_VIBCM;  Q87JE4, PNCB_VIBPA;  
Q8DA38, PNCB_VIBVU;  Q7MK41, PNCB_VIBVY;  Q8PGU5, PNCB_XANAC;  
Q3BPD5, PNCB_XANC5;  Q4UQS8, PNCB_XANC8;  B0RVE9, PNCB_XANCB;  
Q8PCP3, PNCB_XANCP;  Q9PED1, PNCB_XYLFA;  Q87EC4, PNCB_XYLFT;  
A1JMP2, PNCB_YERE8;  A7FJU4, PNCB_YERP3;  Q8ZG93, PNCB_YERPE;  
Q66CG6, PNCB_YERPS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
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