ENZYME entry: EC 6.3.4.22

Accepted Name
tRNA(Ile)(2)-agmatinylcytidine synthase.
Alternative Name(s)
tRNA(Ile)-2-agmatinylcytidine synthetase.
tRNA(Ile)-agm(2)C synthetase.
tRNA(Ile)-agmatidine synthetase.
Reaction catalysed
ATP + agmatine + (tRNA(Ile)(2))-cytidine(34) + H(2)O <=> (tRNA(Ile)(2))-2-agmatinylcytidine(34) + AMP + 2 phosphate
Comment(s)
  • The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNA(Ile)(2) at the oxo group in position 2 of cytidine(34).
  • This modification is crucial for accurate decoding of the genetic code.
  • In bacteria EC 6.3.4.19, catalyzes the modification of (tRNA(Ile)(2))-cytidine(34) to (tRNA(Ile)(2))-lysidine(34).
Cross-references
BRENDA6.3.4.22
EC2PDB6.3.4.22
ExplorEnz6.3.4.22
PRIAM enzyme-specific profiles6.3.4.22
KEGG Ligand Database for Enzyme Nomenclature6.3.4.22
IUBMB Enzyme Nomenclature6.3.4.22
IntEnz6.3.4.22
MEDLINEFind literature relating to 6.3.4.22
MetaCyc6.3.4.22
UniProtKB/Swiss-Prot
D9Q2C4, TIAS_ACIS3;  O28025, TIAS_ARCFU;  A8MA77, TIAS_CALMQ;  
A0RZ60, TIAS_CENSY;  Q18FU7, TIAS_HALWD;  A2BIT1, TIAS_HYPBU;  
E0SPG5, TIAS_IGNAA;  A8A990, TIAS_IGNH4;  Q8TK89, TIAS_METAC;  
Q58495, TIAS_METJA;  Q8TWM9, TIAS_METKA;  A2SPT0, TIAS_METLZ;  
Q8PZP7, TIAS_METMA;  D7DRZ8, TIAS_METV3;  O59476, TIAS_PYRHO;  
B1YAA9, TIAS_PYRNV;  A3DP93, TIAS_STAMF;  C3MRH3, TIAS_SULIL;  
C5A5L9, TIAS_THEGJ;  A1RXS9, TIAS_THEPD;  C6A3Q6, TIAS_THESM;  
Q97B59, TIAS_THEVO;  

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