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ENZYME entry: EC 6.3.4.23

Accepted Name
Formate--phosphoribosylaminoimidazolecarboxamide ligase.
Alternative Name(s)
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase.
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase.
Reaction catalysed
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide <=> ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Comment(s)
  • This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides.
  • It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP.
  • Cf. EC 2.1.2.3.
Cross-references
BRENDA6.3.4.23
EC2PDB6.3.4.23
ExplorEnz6.3.4.23
PRIAM enzyme-specific profiles6.3.4.23
KEGG Ligand Database for Enzyme Nomenclature6.3.4.23
IUBMB Enzyme Nomenclature6.3.4.23
IntEnz6.3.4.23
MEDLINEFind literature relating to 6.3.4.23
MetaCyc6.3.4.23
UniProtKB/Swiss-Prot
Q8PWT3, PURP1_METMA;  Q8PT10, PURP2_METMA;  O30123, PURP_ARCFU;  
A8M9J5, PURP_CALMQ;  A0RU67, PURP_CENSY;  A8A9M3, PURP_IGNH4;  
B1L3X7, PURP_KORCO;  A6UWN1, PURP_META3;  Q8TU67, PURP_METAC;  
Q0W2C6, PURP_METAR;  Q46CU6, PURP_METBF;  Q12VJ6, PURP_METBU;  
Q57600, PURP_METJA;  Q8TXS2, PURP_METKA;  A4FWE6, PURP_METM5;  
A9A9U0, PURP_METM6;  A6VGV9, PURP_METM7;  Q6LXH8, PURP_METMP;  
A5UKI3, PURP_METS3;  A4YCP2, PURP_METS5;  Q2NHH7, PURP_METST;  
O27269, PURP_METTH;  A0B5K9, PURP_METTP;  P14027, PURP_METVS;  
A9A1D3, PURP_NITMS;  Q9V0I8, PURP_PYRAB;  Q8ZYV1, PURP_PYRAE;  
A4WN42, PURP_PYRAR;  A3MTB5, PURP_PYRCJ;  Q8U0R7, PURP_PYRFU;  
O59073, PURP_PYRHO;  A1RQP5, PURP_PYRIL;  B1YBN2, PURP_PYRNV;  
Q4JAU3, PURP_SULAC;  Q980P7, PURP_SULSO;  Q975Y9, PURP_SULTO;  
Q5JFL8, PURP_THEKO;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-