ENZYME entry: EC 6.3.4.3

Accepted Name
Formate--tetrahydrofolate ligase.
Alternative Name(s)
Formyltetrahydrofolate synthetase.
Tetrahydrofolate formylase.
Tetrahydrofolic formylase.
Reaction catalysed
ATP + formate + tetrahydrofolate <=> ADP + phosphate + 10-formyltetrahydrofolate
Comment(s)
In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
Cross-references
PROSITEPDOC00595
BRENDA6.3.4.3
EC2PDB6.3.4.3
ExplorEnz6.3.4.3
PRIAM enzyme-specific profiles6.3.4.3
KEGG Ligand Database for Enzyme Nomenclature6.3.4.3
IUBMB Enzyme Nomenclature6.3.4.3
IntEnz6.3.4.3
MEDLINEFind literature relating to 6.3.4.3
MetaCyc6.3.4.3
UniProtKB/Swiss-Prot
O96553, C1TC_DROME;  P11586, C1TC_HUMAN;  Q922D8, C1TC_MOUSE;  
Q5R8P0, C1TC_PONAB;  P27653, C1TC_RAT;  Q8WZJ7, C1TC_SCHPO;  
Q27772, C1TC_SPOFR;  P07245, C1TC_YEAST;  Q0VCR7, C1TM_BOVIN;  
Q6UB35, C1TM_HUMAN;  Q3V3R1, C1TM_MOUSE;  O43007, C1TM_SCHPO;  
P09440, C1TM_YEAST;  Q251P8, FTHS1_DESHY;  Q5FJY2, FTHS1_LACAC;  
Q1AXZ4, FTHS1_RUBXD;  Q99ZI9, FTHS1_STRP1;  P0DF90, FTHS1_STRP3;  
Q5XC12, FTHS1_STRP6;  Q8P0X5, FTHS1_STRP8;  Q1JBM0, FTHS1_STRPB;  
Q1JLK2, FTHS1_STRPC;  Q1JGN8, FTHS1_STRPD;  Q1J6F7, FTHS1_STRPF;  
A2REC4, FTHS1_STRPG;  Q48TE8, FTHS1_STRPM;  P0DF91, FTHS1_STRPQ;  
A3CL27, FTHS1_STRSV;  Q24ZZ8, FTHS2_DESHY;  Q5FIU5, FTHS2_LACAC;  
Q1AVP8, FTHS2_RUBXD;  Q99XR2, FTHS2_STRP1;  P0DF92, FTHS2_STRP3;  
Q5X9K7, FTHS2_STRP6;  Q8NZ49, FTHS2_STRP8;  Q1J9F2, FTHS2_STRPB;  
Q1JJK1, FTHS2_STRPC;  Q1JEK4, FTHS2_STRPD;  Q1J4C0, FTHS2_STRPF;  
A2RGS2, FTHS2_STRPG;  Q48QZ2, FTHS2_STRPM;  P0DF93, FTHS2_STRPQ;  
A3CN49, FTHS2_STRSV;  Q1AT39, FTHS3_RUBXD;  A9NE95, FTHS_ACHLI;  
A5G276, FTHS_ACICJ;  A3MZI4, FTHS_ACTP2;  B3GX43, FTHS_ACTP7;  
A0KIN9, FTHS_AERHH;  A4SPE5, FTHS_AERS4;  B9J7E8, FTHS_AGRRK;  
B9JZN5, FTHS_AGRVS;  B6EIJ9, FTHS_ALISL;  A8MIN1, FTHS_ALKOO;  
Q9SPK5, FTHS_ARATH;  A1R8N9, FTHS_ARTAT;  A0JZ10, FTHS_ARTS2;  
C3P858, FTHS_BACAA;  C3LKJ6, FTHS_BACAC;  A0RD97, FTHS_BACAH;  
Q81RE1, FTHS_BACAN;  B7JLG8, FTHS_BACC0;  Q739F4, FTHS_BACC1;  
B7IUA4, FTHS_BACC2;  C1ES77, FTHS_BACC3;  B7HP29, FTHS_BACC7;  
B9IYP4, FTHS_BACCQ;  Q81E87, FTHS_BACCR;  Q63C61, FTHS_BACCZ;  
Q5LD60, FTHS_BACFN;  Q64U80, FTHS_BACFR;  Q6HJK9, FTHS_BACHK;  
Q65IA6, FTHS_BACLD;  A8FEC9, FTHS_BACP2;  Q8A9S8, FTHS_BACTN;  
A6L4P0, FTHS_BACV8;  A9IM41, FTHS_BART1;  B2IC30, FTHS_BEII9;  
Q8G700, FTHS_BIFLO;  C0QX38, FTHS_BRAHW;  B9MM59, FTHS_CALBD;  
Q8R7L3, FTHS_CALS4;  A4XIU2, FTHS_CALS8;  A8Z6G1, FTHS_CAMC1;  
A7GZZ0, FTHS_CAMC5;  Q3A9K2, FTHS_CARHZ;  Q11G79, FTHS_CHESB;  
A9WIW3, FTHS_CHLAA;  B8GC03, FTHS_CHLAD;  B9LKW0, FTHS_CHLSY;  
Q97EB3, FTHS_CLOAB;  P13419, FTHS_CLOAC;  A7FZB0, FTHS_CLOB1;  
C3KVU4, FTHS_CLOB6;  A6LPL1, FTHS_CLOB8;  B2UXU5, FTHS_CLOBA;  
B2TI29, FTHS_CLOBB;  A5I7P9, FTHS_CLOBH;  C1FND0, FTHS_CLOBJ;  
B1IGY1, FTHS_CLOBK;  A7GJB8, FTHS_CLOBL;  B1KTC6, FTHS_CLOBM;  
B8I3S9, FTHS_CLOCE;  Q07064, FTHS_CLOCY;  B9DYW1, FTHS_CLOK1;  
A5N5B3, FTHS_CLOK5;  A0PXN0, FTHS_CLONN;  Q0TMI3, FTHS_CLOP1;  
Q8XHL4, FTHS_CLOPE;  A9KNJ5, FTHS_CLOPH;  Q0SQ82, FTHS_CLOPS;  
Q891R3, FTHS_CLOTE;  A3DI22, FTHS_CLOTH;  Q6NH87, FTHS_CORDI;  
Q4JVW2, FTHS_CORJK;  Q3Z8K3, FTHS_DEHM1;  Q3ZX40, FTHS_DEHMC;  
B8FGU7, FTHS_DESAA;  C0QAX9, FTHS_DESAH;  B8J0C2, FTHS_DESDA;  
A8ZZJ0, FTHS_DESOH;  Q6AL19, FTHS_DESPS;  A4J0S6, FTHS_DESRM;  
A8LIR1, FTHS_DINSH;  B2KDK9, FTHS_ELUMP;  Q834D6, FTHS_ENTFA;  
Q5XZD9, FTHS_EUBAC;  C4Z1V6, FTHS_EUBE2;  C4ZBG8, FTHS_EUBR3;  
A7HLZ4, FTHS_FERNB;  B0S0G1, FTHS_FINM2;  Q8RHF4, FTHS_FUSNN;  
Q0BW57, FTHS_GRABC;  Q7VLW6, FTHS_HAEDU;  Q5V5Y2, FTHS_HALMA;  
B8D067, FTHS_HALOH;  Q18JB5, FTHS_HALWD;  B0TBP1, FTHS_HELMI;  
A9B4H8, FTHS_HERA2;  Q0BX04, FTHS_HYPNA;  Q28TR4, FTHS_JANSC;  
C5CI89, FTHS_KOSOT;  Q03S45, FTHS_LACBA;  Q038Y4, FTHS_LACC3;  
B3WEG3, FTHS_LACCB;  Q1GA94, FTHS_LACDA;  Q04AM0, FTHS_LACDB;  
B2GF64, FTHS_LACF3;  Q043I0, FTHS_LACGA;  Q74JC1, FTHS_LACJO;  
Q9CH07, FTHS_LACLA;  A2RLK1, FTHS_LACLM;  Q02ZS7, FTHS_LACLS;  
Q88W76, FTHS_LACPL;  A5VHS9, FTHS_LACRD;  B2G5A9, FTHS_LACRJ;  
Q1WTW0, FTHS_LACS1;  Q38X32, FTHS_LACSS;  Q1MPZ9, FTHS_LAWIP;  
B1MY45, FTHS_LEUCK;  Q03YB1, FTHS_LEUMM;  Q92AD2, FTHS_LISIN;  
C1KWH6, FTHS_LISMC;  Q71YD9, FTHS_LISMF;  B8DDM6, FTHS_LISMH;  
Q8Y624, FTHS_LISMO;  A0AJY2, FTHS_LISW6;  Q0APT3, FTHS_MARMM;  
B7L0A5, FTHS_METC4;  Q605Q9, FTHS_METCA;  Q83WS0, FTHS_METEA;  
A9VZT0, FTHS_METEP;  Q1GZ16, FTHS_METFK;  A2SS72, FTHS_METLZ;  
B8IBS4, FTHS_METNO;  B1ZJ88, FTHS_METPB;  A2SKX8, FTHS_METPP;  
B1M0D1, FTHS_METRJ;  B0UQF5, FTHS_METS4;  B8EKB9, FTHS_METSB;  
Q2RM91, FTHS_MOOTA;  P21164, FTHS_MOOTH;  Q8EUQ1, FTHS_MYCPE;  
Q1DFW5, FTHS_MYXXD;  B2A3Q6, FTHS_NATTJ;  Q5FAG1, FTHS_NEIG1;  
B4RP08, FTHS_NEIG2;  A9M1J1, FTHS_NEIM0;  Q9JVY8, FTHS_NEIMA;  
Q9JXY2, FTHS_NEIMB;  A1KS57, FTHS_NEIMF;  A1SQH3, FTHS_NOCSJ;  
Q04FS6, FTHS_OENOB;  A6LAR6, FTHS_PARD8;  A1B1M8, FTHS_PARDP;  
Q03FM6, FTHS_PEDPA;  Q4FL49, FTHS_PELUB;  Q189R2, FTHS_PEPD6;  
A9BIV8, FTHS_PETMO;  Q6LNJ0, FTHS_PHOPR;  Q6KZM3, FTHS_PICTO;  
Q7MUZ8, FTHS_PORGI;  Q6ABS5, FTHS_PROAC;  B4ET09, FTHS_PROMH;  
A5WI04, FTHS_PSYWF;  A9WMW3, FTHS_RENSM;  B3PV59, FTHS_RHIE6;  
Q2K5P2, FTHS_RHIEC;  Q1MDG4, FTHS_RHIL3;  Q98HQ4, FTHS_RHILO;  
B5ZYA2, FTHS_RHILW;  Q92N42, FTHS_RHIME;  C3MFQ8, FTHS_RHISN;  
A3PM52, FTHS_RHOS1;  Q3J047, FTHS_RHOS4;  A4WQ11, FTHS_RHOS5;  
B9KLK4, FTHS_RHOSK;  A7NGQ9, FTHS_ROSCS;  Q160C2, FTHS_ROSDO;  
A5UPV2, FTHS_ROSS1;  Q5LNV0, FTHS_RUEPO;  Q1GE26, FTHS_RUEST;  
A4FL80, FTHS_SACEN;  A1SAE2, FTHS_SHEAM;  B8ECE1, FTHS_SHEB2;  
A3CZY6, FTHS_SHEB5;  A6WSY9, FTHS_SHEB8;  A9L3Z6, FTHS_SHEB9;  
B0TVP3, FTHS_SHEHH;  A3QA17, FTHS_SHELP;  Q8EJA7, FTHS_SHEON;  
A8H8Z4, FTHS_SHEPA;  A4YAP3, FTHS_SHEPC;  B8CI99, FTHS_SHEPW;  
A0KSN0, FTHS_SHESA;  A8FQV1, FTHS_SHESH;  Q0HMS6, FTHS_SHESM;  
Q0HR05, FTHS_SHESR;  A1RFN3, FTHS_SHESW;  B1KJC0, FTHS_SHEWM;  
A6UBV0, FTHS_SINMW;  O66164, FTHS_SPHPI;  P28723, FTHS_SPIOL;  
A7X3G5, FTHS_STAA1;  A6U2J8, FTHS_STAA2;  Q2FG06, FTHS_STAA3;  
Q2G296, FTHS_STAA8;  A5ITQ4, FTHS_STAA9;  Q2YTF6, FTHS_STAAB;  
Q5HF42, FTHS_STAAC;  A6QHR5, FTHS_STAAE;  Q99TD2, FTHS_STAAM;  
Q7A535, FTHS_STAAN;  Q6GFX6, FTHS_STAAR;  Q6G8J5, FTHS_STAAS;  
A8Z2Q0, FTHS_STAAT;  Q8NW37, FTHS_STAAW;  B9DN77, FTHS_STACT;  
Q5HNH4, FTHS_STAEQ;  Q8CNV9, FTHS_STAES;  Q4L776, FTHS_STAHJ;  
Q3K138, FTHS_STRA1;  Q8E5E3, FTHS_STRA3;  Q8DZP5, FTHS_STRA5;  
C0M9N3, FTHS_STRE4;  B4U2T6, FTHS_STREM;  Q59925, FTHS_STRMU;  
Q04K90, FTHS_STRP2;  B5E4W4, FTHS_STRP4;  C1C7J4, FTHS_STRP7;  
B1IC26, FTHS_STRPI;  B8ZJQ0, FTHS_STRPJ;  Q97QI2, FTHS_STRPN;  
B2IPQ3, FTHS_STRPS;  Q8DPL5, FTHS_STRR6;  A4W0G0, FTHS_STRS2;  
C0MFU5, FTHS_STRS7;  A4VU67, FTHS_STRSY;  Q5M083, FTHS_STRT1;  
Q5M4U2, FTHS_STRT2;  Q03L41, FTHS_STRTD;  B9DS83, FTHS_STRU0;  
C1CEI6, FTHS_STRZJ;  C1CKW9, FTHS_STRZP;  C1CR74, FTHS_STRZT;  
Q67JH9, FTHS_SYMTH;  Q2LU82, FTHS_SYNAS;  A0LLR3, FTHS_SYNFM;  
Q0AX38, FTHS_SYNWW;  B7IG29, FTHS_THEAB;  Q9HI67, FTHS_THEAC;  
A8F7D5, FTHS_THELT;  A6LJS5, FTHS_THEM4;  Q9X287, FTHS_THEMA;  
A5ILJ8, FTHS_THEP1;  B0KC36, FTHS_THEP3;  B0K5A5, FTHS_THEPX;  
B1LAQ7, FTHS_THESQ;  Q72GY9, FTHS_THET2;  Q97CL3, FTHS_THEVO;  
B5YJE1, FTHS_THEYD;  Q73RR6, FTHS_TREDE;  Q9PQS1, FTHS_UREPA;  
A7N5E9, FTHS_VIBCB;  Q9KLX7, FTHS_VIBCH;  Q5E3V8, FTHS_VIBF1;  
B5FG96, FTHS_VIBFM;  Q87HX2, FTHS_VIBPA;  B7VSJ2, FTHS_VIBSL;  
Q8D7D8, FTHS_VIBVU;  Q7MEE8, FTHS_VIBVY;  A1JMA3, FTHS_YERE8;  
Q5NQC7, FTHS_ZYMMO;  

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