ENZYME entry: EC 6.3.4.6

Accepted Name
Urea carboxylase.
Alternative Name(s)
ATP--urea amidolyase.
UALase.
UCA.
Urea amidolyase.
Urea carboxylase (hydrolyzing).
Urease (ATP-hydrolyzing).
Reaction catalysed
ATP + urea + HCO(3)(-) <=> ADP + phosphate + urea-1-carboxylate
Cofactor(s)
Biotin.
Comment(s)
  • The Saccharomyces cerevisiae enzyme (but not that from green algae) also catalyzes the reaction of EC 3.5.1.54, thus bringing about the hydrolysis of urea to CO(2) and NH(3).
  • The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates.
  • Formerly EC 3.5.1.45.
Cross-references
PROSITEPDOC00167 ; PDOC00676 ; PDOC50975 ; PDOC50979
BRENDA6.3.4.6
EC2PDB6.3.4.6
ExplorEnz6.3.4.6
PRIAM enzyme-specific profiles6.3.4.6
KEGG Ligand Database for Enzyme Nomenclature6.3.4.6
IUBMB Enzyme Nomenclature6.3.4.6
IntEnz6.3.4.6
MEDLINEFind literature relating to 6.3.4.6
MetaCyc6.3.4.6
UniProtKB/Swiss-Prot
A5H0J2, DUR1_LACKL;  P32528, DUR1_YEAST;  P38095, LAMA_EMENI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
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