ID 6.3.5.11 DE cobyrinate a,c-diamide synthase (glutamine-hydrolyzing). AN cobyrinic acid a,c-diamide synthetase. CA 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate CA a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate. CC -!- This enzyme is the first glutamine amidotransferase that participates CC in the anaerobic (early cobalt insertion) biosynthetic pathway of CC adenosylcobalamin, and catalyzes the ATP-dependent synthesis of CC cobyrinate a,c-diamide from cobyrinate using either L-glutamine or CC ammonia as the nitrogen source. CC -!- It is proposed that the enzyme first catalyzes the amidation of the CC c-carboxylate, and then the intermediate is released into solution CC and binds to the same catalytic site for the amidation of the CC a-carboxylate. CC -!- The Km for ammonia is substantially higher than that for L-glutamine. CC -!- The equivalent reaction in the aerobic cobalamin biosynthesis pathway CC is catalyzed by EC 6.3.5.9. DR O28054, CBIA_ARCFU ; Q8RCP4, CBIA_CALS4 ; Q97JB1, CBIA_CLOAB ; DR Q897K3, CBIA_CLOTE ; Q3ZA71, CBIA_DEHM1 ; Q3ZWJ9, CBIA_DEHMC ; DR Q8R659, CBIA_FUSNN ; Q7NF32, CBIA_GLOVI ; Q9KBM8, CBIA_HALH5 ; DR Q5V341, CBIA_HALMA ; Q9HPL7, CBIA_HALSA ; A4G3R1, CBIA_HERAR ; DR Q75FQ8, CBIA_LEPIC ; Q8EXQ4, CBIA_LEPIN ; A5VM87, CBIA_LIMRD ; DR B2G9J4, CBIA_LIMRJ ; Q92CL7, CBIA_LISIN ; Q720N8, CBIA_LISMF ; DR Q8Y7T0, CBIA_LISMO ; A0L8B9, CBIA_MAGMM ; Q8TK00, CBIA_METAC ; DR Q46FL0, CBIA_METBF ; Q58816, CBIA_METJA ; A4FW46, CBIA_METM5 ; DR A6VH63, CBIA_METM7 ; A5UMJ2, CBIA_METS3 ; Q2NHQ3, CBIA_METST ; DR O27509, CBIA_METTH ; A6UQC1, CBIA_METVS ; A1AT17, CBIA_PELPD ; DR Q6L2V8, CBIA_PICTO ; O87698, CBIA_PRIMG ; Q980B1, CBIA_SACS2 ; DR P29946, CBIA_SALTY ; A3CL56, CBIA_STRSV ; Q4JAI7, CBIA_SULAC ; DR Q975N0, CBIA_SULTO ; Q3A7A3, CBIA_SYNC1 ; Q5MZU1, CBIA_SYNP6 ; DR P73002, CBIA_SYNY3 ; Q9HIX6, CBIA_THEAC ; Q97BP4, CBIA_THEVO ; //