ID   6.3.5.4
DE   Asparagine synthase (glutamine-hydrolyzing).
AN   AS-B.
AN   Asparagine synthetase (glutamine-hydrolyzing).
AN   Asparagine synthetase B.
AN   Glutamine-dependent asparagine synthetase.
CA   ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate +
CA   L-asparagine + L-glutamate.
CC   -!- The enzyme from Escherichia coli has two active sites that are
CC       connected by an intramolecular ammonia tunnel.
CC   -!- The enzyme catalyzes three distinct chemical reactions: glutamine
CC       hydrolysis to yield ammonia takes place in the N-terminal domain.
CC   -!- The C-terminal active site mediates both the synthesis of a beta-
CC       aspartyl-AMP intermediate and its subsequent reaction with ammonia.
CC   -!- The ammonia released is channeled to the other active site to yield
CC       asparagine.
PR   PROSITE; PDOC00406;
DR   P54420, ASNB_BACSU ;  P22106, ASNB_ECOLI ;  Q58516, ASNH1_METJA;
DR   Q58456, ASNH2_METJA;  P42113, ASNH_BACSU ;  P64248, ASNH_MYCBO ;
DR   P64247, ASNH_MYCTU ;  O05272, ASNO_BACSU ;  P49092, ASNS1_LOTJA;
DR   P19251, ASNS1_PEA  ;  P49089, ASNS1_YEAST;  P49093, ASNS2_LOTJA;
DR   P19252, ASNS2_PEA  ;  P49090, ASNS2_YEAST;  P49078, ASNS_ARATH ;
DR   P31752, ASNS_ASPOF ;  Q1LZA3, ASNS_BOVIN ;  P49091, ASNS_BRAOL ;
DR   Q5ZJU3, ASNS_CHICK ;  P19891, ASNS_CRIGR ;  Q54MB4, ASNS_DICDI ;
DR   P08243, ASNS_HUMAN ;  P49094, ASNS_MAIZE ;  P17714, ASNS_MESAU ;
DR   Q5UQE1, ASNS_MIMIV ;  Q61024, ASNS_MOUSE ;  Q43011, ASNS_ORYSJ ;
DR   Q5R6W9, ASNS_PONAB ;  P49088, ASNS_RAT   ;  O24338, ASNS_SANAU ;
DR   P78753, ASNS_SCHPO ;  O24661, ASNS_TRIVS ;
//