ID   6.3.5.7
DE   Glutaminyl-tRNA synthase (glutamine-hydrolyzing).
AN   Glu-AdT.
AN   Glu-tRNA(Gln) amidotransferase.
AN   Glutamyl-tRNA(Gln) amidotransferase.
CA   ATP + glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + glutaminyl-
CA   tRNA(Gln) + L-glutamate.
CC   -!- In systems lacking discernible EC 6.1.1.18, glutaminyl-tRNA(Gln) is
CC       formed by a two-enzyme system.
CC   -!- In the first step, a nondiscriminating ligase (EC 6.1.1.24)
CC       mischarges tRNA(Gln) with glutamate, forming glutamyl-tRNA(Gln).
CC   -!- The glutamyl-tRNA(Gln) is not used in protein synthesis until the
CC       present enzyme converts it into glutaminyl-tRNA(Gln) (glutamyl-
CC       tRNA(Glu) is not a substrate for this reaction).
CC   -!- Ammonia or asparagine can substitute for the preferred substrate
CC       glutamine.
PR   PROSITE; PDOC00948;
//