ID 6.3.5.9 DE Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing). CA 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H(2)O = 2 ADP + CA 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate. CC -!- This step in the aerobic biosynthesis of cobalamin generates CC hydrogenobyrinic acid a,c-diamide, the substrate required by CC EC 6.6.1.2, which adds cobalt to the macrocycle. //