ID   6.5.1.3
DE   RNA ligase (ATP).
AN   polyribonucleotide synthase (ATP).
AN   ribonucleic ligase.
CA   ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m =
CA   (ribonucleotide)n+m + AMP + diphosphate.
CC   -!- The enzyme catalyzes the ligation of RNA strands with 3'-hydroxyl and
CC       5'-phosphate termini, forming a phosphodiester and sealing certain
CC       types of single-strand breaks in RNA.
CC   -!- Catalysis occurs by a three-step mechanism, starting with the
CC       activation of the enzyme by ATP, forming a phosphoramide bond between
CC       adenylate and a lysine residue.
CC   -!- The adenylate group is then transferred to the 5'-phosphate terminus
CC       of the substrate, forming the capped structure
CC       5'-(5'-diphosphoadenosine)-[RNA].
CC   -!- Finally, the enzyme catalyzes a nucleophilic attack of the 3'-OH
CC       terminus on the capped terminus, which results in formation of the
CC       phosphodiester bond and release of the adenylate.
DR   P86927, RLGM1_TRYB2;  P86926, RLGM1_TRYBB;  P86925, RLGM2_TRYB2;
DR   P86924, RLGM2_TRYBB;  Q2KJ69, RLIG1_BOVIN;  Q5PR55, RLIG1_DANRE;
DR   Q8N999, RLIG1_HUMAN;  Q8BHN7, RLIG1_MOUSE;  Q5RFG5, RLIG1_PONAB;
DR   Q6AXM9, RLIG1_RAT  ;  P32277, RLIG2_BPT4 ;  P00971, RLIG_BPT4  ;
DR   C0HM52, RLIG_BPTS2 ;  P41476, RNL1_NPVAC ;  Q0WL81, RNL_ARATH  ;
DR   P43075, TRNL_CANAL ;  Q10313, TRNL_SCHPO ;  P09880, TRNL_YEAST ;
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