ID   6.6.1.2
DE   cobaltochelatase.
AN   hydrogenobyrinic acid a,c-diamide cobaltochelatase.
CA   ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate
CA   a,c diamide + 5 H(+) + phosphate.
CC   -!- This enzyme, which forms part of the aerobic (late cobalt insertion)
CC       cobalamin biosynthesis pathway, is a type I chelatase, being
CC       heterotrimeric and ATP-dependent.
CC   -!- It comprises two components, one of which corresponds to CobN and the
CC       other is composed of two polypeptides, specified by cobS and cobT in
CC       Pseudomonas denitrificans, and named CobST.
CC   -!- Hydrogenobyrinate is a very poor substrate.
CC   -!- ATP can be replaced by dATP or CTP but the reaction proceeds more
CC       slowly.
CC   -!- CobN exhibits a high affinity for hydrogenobyrinate a,c-diamide.
CC   -!- The oligomeric protein CobST possesses at least one sulfhydryl group
CC       that is essential for ATP-binding.
CC   -!- See EC 4.99.1.3 for the cobaltochelatase that participates in the
CC       anaerobic cobalamin biosynthesis pathway.
DR   Q9HZQ3, COBN_PSEAE ;  P29929, COBN_SINSX ;  P29933, COBS_SINSX ;
DR   P29934, COBT_SINSX ;
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