ID   7.1.1.9
DE   cytochrome-c oxidase.
AN   complex IV (mitochondrial electron transport).
AN   cytochrome a3.
AN   cytochrome aa3.
AN   cytochrome ba3.
AN   cytochrome bb3.
AN   cytochrome caa3.
AN   cytochrome cbb3.
AN   cytochrome oxidase.
AN   Warburg's respiratory enzyme.
CA   4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] +
CA   4 H(+)(out) + 2 H2O.
CC   -!- An oligomeric membrane heme-Cu:O2 reductase-type enzyme that
CC       terminates the respiratory chains of aerobic and facultative aerobic
CC       organisms.
CC   -!- The reduction of O2 to water is accompanied by the extrusion of four
CC       protons.
CC   -!- The cytochrome-aa3 enzymes of mitochondria and many bacterial species
CC       are the most abundant group, but other variations, such as the
CC       bacterial cytochrome-cbb3 enzymes, also exist.
CC   -!- All of the variants have a conserved catalytic core subunit (subunit
CC       I) that contains a low-spin heme (of a- or b-type), a binuclear metal
CC       center composed of a high-spin heme iron (of a-, o-, or b-type heme,
CC       referred to as a3, o3 or b3 heme), and a Cu atom (CuB).
CC   -!- Besides subunit I, the enzyme usually has at least two other core
CC       subunits: subunit II is the primary electron acceptor; subunit III
CC       usually does not contain any cofactors, but in the case of cbb3-type
CC       enzymes it is a diheme c-type cytochrome.
CC   -!- While most bacterial enzymes consist of only 3-4 subunits,
CC       the mitochondrial enzyme is much more complex and contains 14
CC       subunits.
CC   -!- Formerly EC 1.9.3.1.
DR   D9IA43, CCON1_STUST;  P98005, COX13_THET8;  P98057, COX14_BRADU;
DR   Q5YRP8, COX1A_NOCFA;  P08305, COX1A_PARDE;  Q82AK9, COX1A_STRAW;
DR   Q9X813, COX1A_STRCO;  Q5Z0K2, COX1B_NOCFA;  P98002, COX1B_PARDE;
DR   Q828X4, COX1B_STRAW;  Q9K451, COX1B_STRCO;  Q37370, COX1_ACACA ;
DR   B0FWC7, COX1_AEDAE ;  P68540, COX1_AEGCO ;  P48887, COX1_ALBCA ;
DR   Q09333, COX1_ALBTU ;  Q04440, COX1_ALKPO ;  P80440, COX1_ALLMA ;
DR   P29643, COX1_AMICA ;  P50656, COX1_ANAPL ;  P34838, COX1_ANOGA ;
DR   P33504, COX1_ANOQU ;  P20374, COX1_APILI ;  O03515, COX1_APTAU ;
DR   P60620, COX1_ARATH ;  Q37705, COX1_ARTSF ;  P24881, COX1_ASCSU ;
DR   P29644, COX1_ATRSP ;  P16262, COX1_BACP3 ;  P24010, COX1_BACSU ;
DR   Q599A1, COX1_BALBO ;  P41293, COX1_BALMU ;  P24983, COX1_BALPH ;
DR   P24794, COX1_BETVU ;  Q36724, COX1_BLAGE ;  Q6EMS9, COX1_BOSIN ;
DR   Q5Y4Q8, COX1_BOSMU ;  P00396, COX1_BOVIN ;  P31833, COX1_BRADU ;
DR   Q94WR7, COX1_BUTBU ;  P24893, COX1_CAEEL ;  P0C8K9, COX1_CANAL ;
DR   Q85QA3, COX1_CANGA ;  Q9ZZ64, COX1_CANLF ;  Q1HKA1, COX1_CANLU ;
DR   Q33375, COX1_CANSI ;  Q36347, COX1_CAPHI ;  O78681, COX1_CARAU ;
DR   O03521, COX1_CASBE ;  O03198, COX1_CERSI ;  P33517, COX1_CERSP ;
DR   P18943, COX1_CHICK ;  P08681, COX1_CHLRE ;  P50668, COX1_CHOBI ;
DR   P48866, COX1_CHOCR ;  P50669, COX1_CHOFU ;  P67793, COX1_CHOOC ;
DR   P67794, COX1_CHOPI ;  P50671, COX1_CHORO ;  Q9B229, COX1_CHRKN ;
DR   O99041, COX1_COLPO ;  Q6NFM3, COX1_CORDI ;  Q8FMT1, COX1_COREF ;
DR   Q79VD7, COX1_CORGL ;  P24984, COX1_COTJA ;  Q6EGJ1, COX1_CRANE ;
DR   Q6EGJ0, COX1_CRAZI ;  P48867, COX1_CYACA ;  P24985, COX1_CYPCA ;
DR   Q9MIY8, COX1_DANRE ;  O21327, COX1_DASNO ;  A9RAH5, COX1_DEBHA ;
DR   Q2LCQ6, COX1_DICCI ;  O21042, COX1_DICDI ;  P41310, COX1_DIDVI ;
DR   Q8WEW4, COX1_DORPE ;  Q34345, COX1_DROMA ;  P00399, COX1_DROME ;
DR   O03524, COX1_DRONO ;  Q34391, COX1_DROSE ;  Q34388, COX1_DROSI ;
DR   P00400, COX1_DROYA ;  Q8W9N4, COX1_DUGDU ;  Q2I3H2, COX1_ELEMA ;
DR   P00402, COX1_EMEND ;  Q33439, COX1_EPHMA ;  P92477, COX1_EQUAS ;
DR   P62514, COX1_EREGS ;  P48888, COX1_FELCA ;  P34188, COX1_FORLA ;
DR   Q36775, COX1_GADMO ;  Q6EGH9, COX1_GEOBE ;  P29645, COX1_GEOSD ;
DR   Q6EGH8, COX1_GEOTE ;  P29646, COX1_GOMVA ;  P38595, COX1_HALGR ;
DR   P33518, COX1_HALSA ;  Q9ZZ08, COX1_HAPMA ;  Q9ZZY9, COX1_HIPAM ;
DR   P48659, COX1_HORSE ;  P00395, COX1_HUMAN ;  Q7GEN7, COX1_HYLLA ;
DR   P20386, COX1_KLULA ;  O03167, COX1_LATCH ;  P14544, COX1_LEITA ;
DR   Q8LX30, COX1_LEMCA ;  P29647, COX1_LEPOC ;  Q36421, COX1_LOCMI ;
DR   Q9TGE6, COX1_LOLFO ;  Q9TA27, COX1_LOXAF ;  Q34941, COX1_LUMTE ;
DR   O79548, COX1_LYCSM ;  P08742, COX1_MAIZE ;  Q38PS0, COX1_MAMPR ;
DR   P26856, COX1_MARPO ;  P29648, COX1_MEGAT ;  Q35101, COX1_METSE ;
DR   P00397, COX1_MOUSE ;  P63853, COX1_MYCBO ;  Q9CBQ5, COX1_MYCLE ;
DR   Q73VC3, COX1_MYCPA ;  P9WP70, COX1_MYCTO ;  P9WP71, COX1_MYCTU ;
DR   P41774, COX1_MYTED ;  O21079, COX1_MYXGL ;  P03945, COX1_NEUCR ;
DR   O03539, COX1_NOTPE ;  Q9G6J1, COX1_OCTVU ;  P08743, COX1_OENBE ;
DR   P48170, COX1_ONCMY ;  Q36452, COX1_ORNAN ;  Q6EGI5, COX1_ORTCH ;
DR   Q6EGI2, COX1_ORTGR ;  Q6EGI3, COX1_ORTHI ;  Q6EGI4, COX1_ORTUN ;
DR   P14578, COX1_ORYSJ ;  P92661, COX1_OSPRO ;  Q9B840, COX1_OSTNU ;
DR   P29649, COX1_PANBU ;  Q9T9X0, COX1_PANPA ;  Q9T9W1, COX1_PANTR ;
DR   Q6EGI0, COX1_PAPBU ;  Q9ZXY2, COX1_PAPHA ;  P12700, COX1_PARLI ;
DR   P05489, COX1_PARTE ;  Q00502, COX1_PARVE ;  Q33820, COX1_PATPE ;
DR   P12786, COX1_PEA   ;  Q96000, COX1_PECMA ;  O79672, COX1_PELSU ;
DR   Q35536, COX1_PETMA ;  Q00527, COX1_PHOVI ;  Q02211, COX1_PHYME ;
DR   Q07434, COX1_PHYPO ;  O79876, COX1_PIG   ;  P25001, COX1_PISOC ;
DR   O99252, COX1_PLABE ;  O99255, COX1_PLACH ;  Q9TGD8, COX1_PLADA ;
DR   Q02766, COX1_PLAFA ;  P20681, COX1_PODAN ;  Q95911, COX1_POLOR ;
DR   P29650, COX1_POLSP ;  P29651, COX1_POLSX ;  P29652, COX1_POMNI ;
DR   P92692, COX1_PONAB ;  Q05143, COX1_PROWI ;  O79429, COX1_RABIT ;
DR   P60621, COX1_RAPSA ;  P05503, COX1_RAT   ;  O03546, COX1_RHEAM ;
DR   Q08855, COX1_RHILE ;  O99818, COX1_RHISA ;  Q96062, COX1_RHIUN ;
DR   P98059, COX1_RHOCA ;  Q1RI42, COX1_RICBR ;  Q92I67, COX1_RICCN ;
DR   Q4ULU5, COX1_RICFE ;  O54069, COX1_RICPR ;  P98001, COX1_SACPA ;
DR   Q9ZZM6, COX1_SALSA ;  P29653, COX1_SALTR ;  P29654, COX1_SCAPL ;
DR   P07657, COX1_SCHPO ;  O79403, COX1_SCYCA ;  Q8WEW3, COX1_SEPOF ;
DR   Q957T2, COX1_SEPPH ;  O78749, COX1_SHEEP ;  P05502, COX1_SORBI ;
DR   P07506, COX1_SOYBN ;  Q9ZZ52, COX1_SQUAC ;  O21399, COX1_STRCA ;
DR   P98003, COX1_STROO ;  P15544, COX1_STRPU ;  Q34800, COX1_SYMSY ;
DR   Q06473, COX1_SYNY3 ;  Q4JQI5, COX1_TETNG ;  P11947, COX1_TETPY ;
DR   Q4UJ69, COX1_THEAN ;  Q36097, COX1_THEPA ;  Q5SJ79, COX1_THET8 ;
DR   Q56408, COX1_THETH ;  P50676, COX1_THEVL ;  O03554, COX1_TINMA ;
DR   Q01555, COX1_TRIRU ;  P04371, COX1_TRYBB ;  Q0H8Y4, COX1_USTMA ;
DR   A6H4Q6, COX1_VANPO ;  P68539, COX1_WHEAT ;  P48868, COX1_WICCA ;
DR   P00398, COX1_XENLA ;  Q9B6E7, COX1_YARLI ;  P00401, COX1_YEAST ;
DR   Q6EGH7, COX1_ZYGTR ;  P29870, COX2_ACHDO ;  Q38S50, COX2_ACOIG ;
DR   P50672, COX2_ACOWI ;  P29871, COX2_ADABI ;  P50692, COX2_AEDAE ;
DR   Q3L6W7, COX2_AILFU ;  Q2Y0B9, COX2_AILME ;  P48889, COX2_ALBCA ;
DR   Q09334, COX2_ALBTU ;  Q04441, COX2_ALKPO ;  O47870, COX2_ALLMI ;
DR   P98024, COX2_ALOPA ;  P29655, COX2_AMICA ;  P98019, COX2_ANAPL ;
DR   Q38S38, COX2_ANIIM ;  P34840, COX2_ANOGA ;  P33505, COX2_ANOQU ;
DR   Q37369, COX2_ANTAM ;  Q7IC90, COX2_AOTNI ;  P50267, COX2_APIFL ;
DR   P50268, COX2_APIKO ;  P20375, COX2_APILI ;  Q38S35, COX2_APOMY ;
DR   Q38S29, COX2_APOSM ;  P50673, COX2_APOSY ;  O03889, COX2_APTAU ;
DR   P93285, COX2_ARATH ;  Q37706, COX2_ARTSF ;  Q38S26, COX2_ARVSO ;
DR   P24882, COX2_ASCSU ;  Q7J6G4, COX2_ATEMI ;  P29656, COX2_ATRSP ;
DR   Q03438, COX2_BACP3 ;  P24011, COX2_BACSU ;  Q599A0, COX2_BALBO ;
DR   P41294, COX2_BALMU ;  P24986, COX2_BALPH ;  Q38S23, COX2_BATGR ;
DR   Q38S20, COX2_BERBO ;  P98012, COX2_BETVU ;  Q37416, COX2_BISBI ;
DR   P68296, COX2_BISBO ;  P68295, COX2_BOSGA ;  P68553, COX2_BOSIN ;
DR   P68294, COX2_BOSJA ;  P68554, COX2_BOSMU ;  Q37419, COX2_BOSTR ;
DR   P68530, COX2_BOVIN ;  O47428, COX2_BRAFL ;  Q9GCE7, COX2_BRAHY ;
DR   O79417, COX2_BRALA ;  P43369, COX2_BREAN ;  P43370, COX2_BRECS ;
DR   P43372, COX2_BRENA ;  P50678, COX2_BUBDE ;  Q8HEC3, COX2_CAEBR ;
DR   P24894, COX2_CAEEL ;  Q8SEM9, COX2_CAERE ;  P50666, COX2_CAIMO ;
DR   P50661, COX2_CALGO ;  O47667, COX2_CANAD ;  Q9B8D8, COX2_CANAL ;
DR   O47669, COX2_CANAU ;  P43373, COX2_CANGA ;  P67781, COX2_CANLA ;
DR   P67780, COX2_CANLF ;  P67782, COX2_CANLU ;  O47671, COX2_CANME ;
DR   P98031, COX2_CANSI ;  Q37430, COX2_CAPHI ;  O78682, COX2_CARAU ;
DR   P98046, COX2_CARSF ;  O03890, COX2_CASBE ;  P50683, COX2_CAVAP ;
DR   P98043, COX2_CEPBA ;  P98020, COX2_CERGA ;  O03851, COX2_CERSI ;
DR   Q03736, COX2_CERSP ;  O47672, COX2_CERTH ;  P98027, COX2_CHEME ;
DR   P18944, COX2_CHICK ;  P26455, COX2_CHLAE ;  P98025, COX2_CHOBI ;
DR   P48869, COX2_CHOCR ;  P84288, COX2_CHOFU ;  P84289, COX2_CHOOC ;
DR   P84290, COX2_CHOPI ;  P98030, COX2_CHORO ;  O47670, COX2_CHRBR ;
DR   Q38S17, COX2_CONPN ;  Q6NG98, COX2_CORDI ;  Q8FNQ7, COX2_COREF ;
DR   Q8NNK2, COX2_CORGL ;  P50684, COX2_COTJA ;  P50685, COX2_CRABU ;
DR   P50662, COX2_CRACA ;  P29872, COX2_CTEFE ;  P50693, COX2_CULQU ;
DR   O47668, COX2_CUOAL ;  P48870, COX2_CYACA ;  P47918, COX2_CYBMR ;
DR   P06029, COX2_CYBSA ;  P24987, COX2_CYPCA ;  Q38S14, COX2_DACMI ;
DR   P50679, COX2_DAMPP ;  Q9MIY7, COX2_DANRE ;  P50687, COX2_DASNO ;
DR   P27168, COX2_DAUCA ;  P98032, COX2_DAUMA ;  A9RAG1, COX2_DEBHA ;
DR   P43374, COX2_DEKBR ;  Q38S65, COX2_DESAU ;  P41311, COX2_DIDVI ;
DR   Q85TA0, COX2_DROAI ;  P84201, COX2_DROAL ;  P29856, COX2_DROAM ;
DR   P84202, COX2_DROAT ;  P84287, COX2_DROAZ ;  P29859, COX2_DROBF ;
DR   P29860, COX2_DROLO ;  P00408, COX2_DROME ;  P67797, COX2_DROMI ;
DR   O03891, COX2_DRONO ;  P67795, COX2_DRONR ;  P67798, COX2_DROPE ;
DR   P67799, COX2_DROPS ;  P50253, COX2_DROSI ;  P29865, COX2_DROSU ;
DR   P67796, COX2_DROTO ;  P00409, COX2_DROYA ;  Q8W9N3, COX2_DUGDU ;
DR   P43375, COX2_EENNA ;  Q2I3H1, COX2_ELEMA ;  P13588, COX2_EMEND ;
DR   P92478, COX2_EQUAS ;  Q7YFV7, COX2_EREGS ;  P98033, COX2_EULMA ;
DR   P29873, COX2_EXERO ;  P48890, COX2_FELCA ;  P34189, COX2_FORLA ;
DR   Q37741, COX2_GADMO ;  P29874, COX2_GALME ;  P50688, COX2_GALSE ;
DR   P50686, COX2_GALVR ;  P50680, COX2_GAZSP ;  P50689, COX2_GEOCP ;
DR   P29657, COX2_GEOSD ;  Q38S62, COX2_GERGE ;  Q38S56, COX2_GERRO ;
DR   Q37476, COX2_GERVA ;  P29658, COX2_GOMVA ;  Q37472, COX2_GORBE ;
DR   P26456, COX2_GORGO ;  P38596, COX2_HALGR ;  P98034, COX2_HAPGR ;
DR   Q9ZZY8, COX2_HIPAM ;  P48660, COX2_HORSE ;  P00403, COX2_HUMAN ;
DR   Q38S11, COX2_HYBUN ;  Q96127, COX2_HYLLA ;  Q38S08, COX2_HYLPR ;
DR   P43377, COX2_KAZEX ;  P20387, COX2_KLULA ;  Q9XLW8, COX2_LACK1 ;
DR   P43376, COX2_LACTC ;  P98036, COX2_LAGLA ;  P29875, COX2_LASSP ;
DR   O03848, COX2_LATCH ;  Q38S05, COX2_LEGFO ;  P14545, COX2_LEITA ;
DR   Q38S02, COX2_LEMBA ;  P98035, COX2_LEMCA ;  Q38S00, COX2_LEOSA ;
DR   P29659, COX2_LEPOC ;  P14573, COX2_LOCMI ;  Q38S47, COX2_LOPFL ;
DR   Q9TA26, COX2_LOXAF ;  Q37545, COX2_LUMTE ;  O47676, COX2_LYCCU ;
DR   O48267, COX2_LYCGR ;  O47677, COX2_LYCGY ;  O47674, COX2_LYCPI ;
DR   O47678, COX2_LYCSE ;  O79549, COX2_LYCSM ;  Q7J6G2, COX2_LYCVE ;
DR   Q37548, COX2_MACCA ;  P11948, COX2_MACFA ;  P98038, COX2_MACMU ;
DR   P00412, COX2_MAIZE ;  Q38RZ7, COX2_MALLO ;  Q37547, COX2_MALTY ;
DR   Q38PR9, COX2_MAMPR ;  P98037, COX2_MANLE ;  P26857, COX2_MARPO ;
DR   Q38RZ2, COX2_MAXBA ;  Q38RY9, COX2_MAXSU ;  P29660, COX2_MEGAT ;
DR   Q38S59, COX2_MERSH ;  O47496, COX2_METSE ;  Q38S41, COX2_MICNA ;
DR   P24988, COX2_MICPE ;  Q7IKU8, COX2_MICTV ;  P00405, COX2_MOUSE ;
DR   P63855, COX2_MYCBO ;  Q9CCF1, COX2_MYCLE ;  Q73YL5, COX2_MYCPA ;
DR   P9WP68, COX2_MYCTO ;  P9WP69, COX2_MYCTU ;  Q00227, COX2_MYTED ;
DR   Q9G2X2, COX2_MYXGL ;  P00411, COX2_NEUCR ;  Q38RY6, COX2_NIVCU ;
DR   Q5YZ37, COX2_NOCFA ;  O03892, COX2_NOTPE ;  P98039, COX2_NYCCO ;
DR   O47675, COX2_NYCPR ;  P05490, COX2_OENBE ;  Q38RY0, COX2_OENHY ;
DR   P29876, COX2_ONCFA ;  P48171, COX2_ONCMY ;  Q37718, COX2_ORNAN ;
DR   P04373, COX2_ORYSJ ;  P92662, COX2_OSPRO ;  P26457, COX2_PANPA ;
DR   P50690, COX2_PANTR ;  P68297, COX2_PAPAN ;  P68298, COX2_PAPHA ;
DR   P08306, COX2_PARDE ;  P12701, COX2_PARLI ;  P08748, COX2_PARPR ;
DR   P08749, COX2_PARTE ;  Q37411, COX2_PATPE ;  P08744, COX2_PEA   ;
DR   O79673, COX2_PELSU ;  P29877, COX2_PERAM ;  Q37595, COX2_PERFA ;
DR   Q37604, COX2_PETMA ;  Q00528, COX2_PHOVI ;  Q37596, COX2_PHYHA ;
DR   Q02212, COX2_PHYME ;  P50667, COX2_PIG   ;  P25002, COX2_PISOC ;
DR   P29163, COX2_PNECA ;  P20682, COX2_PODAN ;  Q96183, COX2_POLOR ;
DR   P29661, COX2_POLSX ;  P92693, COX2_PONAB ;  Q37605, COX2_PONPY ;
DR   Q38RX1, COX2_PRAJA ;  Q38RW8, COX2_PRATA ;  Q38RW5, COX2_PRATU ;
DR   P98042, COX2_PROTA ;  P98049, COX2_RABIT ;  P00406, COX2_RAT   ;
DR   Q38RV6, COX2_RHAPU ;  O03893, COX2_RHEAM ;  Q37643, COX2_RHIDA ;
DR   O99819, COX2_RHISA ;  Q96190, COX2_RHIUN ;  Q38RV3, COX2_RHYIS ;
DR   Q1RI44, COX2_RICBR ;  Q92I65, COX2_RICCN ;  Q4ULU3, COX2_RICFE ;
DR   Q9ZDC6, COX2_RICPR ;  Q37649, COX2_ROULE ;  Q37440, COX2_RUSUN ;
DR   Q37677, COX2_SALSA ;  P29662, COX2_SCAPL ;  P29878, COX2_SCHGR ;
DR   P21534, COX2_SCHPO ;  P50691, COX2_SCICA ;  O79404, COX2_SCYCA ;
DR   O78750, COX2_SHEEP ;  P98021, COX2_SIMVI ;  P29879, COX2_SITGR ;
DR   P80498, COX2_SOLTU ;  P05491, COX2_SOYBN ;  O47679, COX2_SPEVE ;
DR   Q9ZZ51, COX2_SQUAC ;  Q82AL0, COX2_STRAW ;  O21400, COX2_STRCA ;
DR   Q9X814, COX2_STRCO ;  P15545, COX2_STRPU ;  Q38RU7, COX2_SUNME ;
DR   P29880, COX2_SYMST ;  P25312, COX2_SYMSY ;  P50675, COX2_SYNCA ;
DR   Q06474, COX2_SYNY3 ;  Q37691, COX2_TACSP ;  Q7IZ21, COX2_TAMAM ;
DR   Q7IZ16, COX2_TAMBU ;  Q7IZ15, COX2_TAMCA ;  Q7IZ14, COX2_TAMCI ;
DR   Q7IZ11, COX2_TAMDO ;  Q7IZ08, COX2_TAMMR ;  Q7IZ01, COX2_TAMPL ;
DR   Q9G5S9, COX2_TAMQA ;  Q9G1N5, COX2_TAMRF ;  Q9G0U1, COX2_TAMSO ;
DR   Q9G185, COX2_TAMTO ;  Q38S53, COX2_TATEM ;  Q4JQI4, COX2_TETNG ;
DR   P98044, COX2_THEGE ;  Q5SJ80, COX2_THET8 ;  P98052, COX2_THETH ;
DR   P98054, COX2_THEVL ;  O03895, COX2_TINMA ;  Q37685, COX2_TRAIM ;
DR   Q01556, COX2_TRIRU ;  P04372, COX2_TRYBB ;  P98023, COX2_TRYCR ;
DR   Q37684, COX2_TUPGL ;  Q38RU4, COX2_UROCA ;  O48276, COX2_UROCI ;
DR   Q0H8Y7, COX2_USTMA ;  A6H4Q5, COX2_VANPO ;  P98047, COX2_VARVI ;
DR   P32646, COX2_VIGUN ;  Q539C6, COX2_VULCO ;  O47680, COX2_VULMA ;
DR   O47681, COX2_VULVU ;  O47673, COX2_VULZE ;  P00413, COX2_WHEAT ;
DR   P48871, COX2_WICCA ;  P00407, COX2_XENLA ;  Q9B6D5, COX2_YARLI ;
DR   P00410, COX2_YEAST ;  P98048, COX2_YPOMA ;  Q3T4C0, COX2_ZANCU ;
DR   Q38RU1, COX2_ZELHI ;  P29881, COX2_ZOOAN ;  Q37374, COX3_ACACA ;
DR   B0FWD1, COX3_AEDAE ;  Q36952, COX3_AEGCO ;  O47691, COX3_AEPME ;
DR   P48891, COX3_ALBCA ;  Q04442, COX3_ALKPO ;  P80439, COX3_ALLMA ;
DR   P50657, COX3_ANAPL ;  P34842, COX3_ANOGA ;  P33508, COX3_ANOQU ;
DR   O47702, COX3_ANTCE ;  O47701, COX3_ANTMR ;  P34843, COX3_APILI ;
DR   P92514, COX3_ARATH ;  Q33752, COX3_ARBLI ;  Q33845, COX3_ARTSA ;
DR   Q36309, COX3_ARTSF ;  P24879, COX3_ASCSU ;  Q03439, COX3_BACP3 ;
DR   P24012, COX3_BACSU ;  P41295, COX3_BALMU ;  P24989, COX3_BALPH ;
DR   Q576B8, COX3_BOSIN ;  Q5Y4Q4, COX3_BOSMU ;  P00415, COX3_BOVIN ;
DR   P69216, COX3_BRAFL ;  P69215, COX3_BRALA ;  P24891, COX3_CAEEL ;
DR   Q9B1P9, COX3_CANAL ;  Q85Q96, COX3_CANGA ;  Q9ZZ61, COX3_CANLF ;
DR   Q1HK97, COX3_CANLU ;  Q34214, COX3_CANPA ;  Q96133, COX3_CARAU ;
DR   O47693, COX3_CEPNA ;  O03201, COX3_CERSI ;  P18945, COX3_CHICK ;
DR   P48872, COX3_CHOCR ;  Q6NGA0, COX3_CORDI ;  Q8FNQ9, COX3_COREF ;
DR   Q9AEL8, COX3_CORGL ;  Q8SEW8, COX3_COTJA ;  P48873, COX3_CYACA ;
DR   P15952, COX3_CYPCA ;  O47694, COX3_DAMLU ;  Q9MIY4, COX3_DANRE ;
DR   O21331, COX3_DASNO ;  A9RAG9, COX3_DEBHA ;  Q2LCP9, COX3_DICCI ;
DR   O21049, COX3_DICDI ;  P41312, COX3_DIDVI ;  P00417, COX3_DROME ;
DR   P50271, COX3_DROSI ;  P00418, COX3_DROYA ;  Q8W9N0, COX3_DUGDU ;
DR   Q2I3G8, COX3_ELEMA ;  P00421, COX3_EMEND ;  Q35242, COX3_ENTDO ;
DR   P92481, COX3_EQUAS ;  Q75G34, COX3_EREGS ;  O47705, COX3_EUDRU ;
DR   O47706, COX3_EUDTH ;  P48892, COX3_FELCA ;  P34198, COX3_FORLA ;
DR   P55777, COX3_GADMO ;  P68531, COX3_GAZBE ;  O47708, COX3_GAZCU ;
DR   P68299, COX3_GAZDO ;  P68532, COX3_GAZGA ;  O47709, COX3_GAZLE ;
DR   O47710, COX3_GAZSA ;  P68300, COX3_GAZSP ;  O48316, COX3_GAZSU ;
DR   Q9T9Y6, COX3_GORGO ;  P38597, COX3_HALGR ;  P32808, COX3_HELAN ;
DR   O47475, COX3_HETBL ;  Q9ZZY5, COX3_HIPAM ;  P48661, COX3_HORSE ;
DR   P00414, COX3_HUMAN ;  Q95707, COX3_HYLLA ;  Q9XLW9, COX3_KLULA ;
DR   Q9XLX0, COX3_LACK1 ;  O03170, COX3_LATCH ;  P14546, COX3_LEITA ;
DR   Q8LX26, COX3_LEMCA ;  O47700, COX3_LITWA ;  P14574, COX3_LOCMI ;
DR   Q2I3F5, COX3_LOXAF ;  Q34943, COX3_LUMTE ;  O79552, COX3_LYCSM ;
DR   O47699, COX3_MADGU ;  P09138, COX3_MAIZE ;  Q38PR6, COX3_MAMPR ;
DR   P26858, COX3_MARPO ;  O47491, COX3_METSE ;  P00416, COX3_MOUSE ;
DR   P63857, COX3_MYCBO ;  O69582, COX3_MYCLE ;  Q73YM3, COX3_MYCPA ;
DR   P9WP66, COX3_MYCTO ;  P9WP67, COX3_MYCTU ;  P41775, COX3_MYTED ;
DR   O63915, COX3_MYXGL ;  O48374, COX3_NANDA ;  P68088, COX3_NANGR ;
DR   P68089, COX3_NANSO ;  O47698, COX3_NEOMO ;  P00422, COX3_NEUCR ;
DR   Q5YZ19, COX3_NOCFA ;  P08745, COX3_OENBE ;  P20684, COX3_ONCCL ;
DR   P69217, COX3_ONCMA ;  P48172, COX3_ONCMY ;  P69218, COX3_ONCNE ;
DR   Q36455, COX3_ORNAN ;  P14852, COX3_ORYSI ;  P92665, COX3_OSPRO ;
DR   O47695, COX3_OUROU ;  Q9T9W8, COX3_PANPA ;  Q9T9V9, COX3_PANTR ;
DR   Q9ZXX8, COX3_PAPHA ;  P06030, COX3_PARDE ;  P12702, COX3_PARLI ;
DR   Q33824, COX3_PATPE ;  O47692, COX3_PELCP ;  O79676, COX3_PELSU ;
DR   Q35539, COX3_PETMA ;  Q00529, COX3_PHOVI ;  Q35916, COX3_PIG   ;
DR   P25003, COX3_PISOC ;  Q36675, COX3_PLAVI ;  Q02654, COX3_PODAN ;
DR   Q95914, COX3_POLOR ;  P92696, COX3_PONAB ;  Q9T9X6, COX3_PONPY ;
DR   Q37620, COX3_PROWI ;  Q37600, COX3_PYLLI ;  Q95840, COX3_PYRGI ;
DR   O79433, COX3_RABIT ;  O47696, COX3_RAPCA ;  O47697, COX3_RAPME ;
DR   P05505, COX3_RAT   ;  O99822, COX3_RHISA ;  P80441, COX3_RHIST ;
DR   Q96065, COX3_RHIUN ;  Q1RHH9, COX3_RICBR ;  Q92J29, COX3_RICCN ;
DR   Q4UKK0, COX3_RICFE ;  Q9ZDX3, COX3_RICPR ;  Q36860, COX3_SALSA ;
DR   P14058, COX3_SCHCO ;  P14575, COX3_SCHPO ;  O79407, COX3_SCYCA ;
DR   O21619, COX3_SHEEP ;  P14853, COX3_SOYBN ;  Q35826, COX3_SPOFR ;
DR   Q9ZZ48, COX3_SQUAC ;  Q82AK5, COX3_STRAW ;  O21403, COX3_STRCA ;
DR   Q9X809, COX3_STRCO ;  P15546, COX3_STRPU ;  O47690, COX3_SYNCA ;
DR   Q06475, COX3_SYNY3 ;  Q8W9G7, COX3_TACAC ;  Q4JQI1, COX3_TETNG ;
DR   Q37679, COX3_THEAN ;  Q36098, COX3_THEPA ;  P50677, COX3_THEVL ;
DR   O47685, COX3_TRAIM ;  O47686, COX3_TRAOR ;  O47688, COX3_TRASP ;
DR   O47687, COX3_TRASR ;  O47689, COX3_TRAST ;  Q36837, COX3_TRIRU ;
DR   Q37355, COX3_TRYBO ;  Q0H8X4, COX3_USTMA ;  A6H4Q3, COX3_VANPO ;
DR   Q03227, COX3_VICFA ;  P15953, COX3_WHEAT ;  P48874, COX3_WICCA ;
DR   P00419, COX3_XENLA ;  Q9B6D8, COX3_YARLI ;  P00420, COX3_YEAST ;
DR   Q04452, COX4_ALKPO ;  Q03440, COX4_BACP3 ;  P24013, COX4_BACSU ;
DR   Q6NG99, COX4_CORDI ;  Q8FNQ8, COX4_COREF ;  Q8NNK3, COX4_CORGL ;
DR   P30815, COX4_DICDI ;  P64948, COX4_MYCBO ;  Q9CCF0, COX4_MYCLE ;
DR   Q73YL6, COX4_MYCPA ;  P9WP44, COX4_MYCTO ;  P9WP45, COX4_MYCTU ;
DR   Q5YZ36, COX4_NOCFA ;  P77921, COX4_PARDE ;  Q82AK8, COX4_STRAW ;
DR   Q9X812, COX4_STRCO ;  P82543, COXA_THET8 ;  P20609, COXE_DICDI ;
DR   P98053, COXM_BRADU ;  P80981, COXM_THUOB ;  P98000, COXN_BRADU ;
DR   P80980, COXN_THUOB ;  P20610, COXS_DICDI ;  Q02226, COXT_SOYBN ;
DR   P98055, FIXN_AGRT7 ;  P98056, FIXN_AZOC5 ;  Q03073, FIXN_BRADU ;
DR   Q05572, FIXN_RHIME ;
//