ENZYME entry: EC 7.2.2.10

Accepted Name

P-type Ca(2+) transporter

Alternative Name(s)

Ca(2+)-transporting ATPase

calcium pump

calcium-translocating P-type ATPase

Reaction catalysed

ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate

Comment(s)

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria.
The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed.
In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum.
Formerly EC 3.6.3.8.

Cross-references

BRENDA

7.2.2.10

EC2PDB

7.2.2.10

ExplorEnz

7.2.2.10

PRIAM enzyme-specific profiles

7.2.2.10

KEGG Ligand Database for Enzyme Nomenclature

7.2.2.10

IUBMB Enzyme Nomenclature

7.2.2.10

IntEnz

7.2.2.10

MEDLINE

Find literature relating to 7.2.2.10

MetaCyc

7.2.2.10

Rhea expert-curated reactions

7.2.2.10

UniProtKB/Swiss-Prot

Q9SZR1, ACA10_ARATH	Q2QMX9, ACA10_ORYSJ	Q9M2L4, ACA11_ARATH
Q9LY77, ACA12_ARATH	Q9LIK7, ACA13_ARATH	Q37145, ACA1_ARATH
Q8RUN1, ACA1_ORYSJ	O81108, ACA2_ARATH	Q6ATV4, ACA3_ORYSJ
O22218, ACA4_ARATH	Q7X8B5, ACA5_ORYSJ	Q65X71, ACA6_ORYSJ
O64806, ACA7_ARATH	Q7XEK4, ACA7_ORYSJ	Q9LF79, ACA8_ARATH
Q2RAS0, ACA8_ORYSJ	Q9LU41, ACA9_ARATH	Q2QY12, ACA9_ORYSJ
Q0VCY0, AT2A1_BOVIN	P13585, AT2A1_CHICK	O14983, AT2A1_HUMAN
P70083, AT2A1_MAKNI	Q8R429, AT2A1_MOUSE	Q92105, AT2A1_PELLE
P04191, AT2A1_RABIT	Q64578, AT2A1_RAT	O46674, AT2A2_CANLF
Q03669, AT2A2_CHICK	Q00779, AT2A2_FELCA	P16615, AT2A2_HUMAN
O55143, AT2A2_MOUSE	P11607, AT2A2_PIG	P20647, AT2A2_RABIT
P11507, AT2A2_RAT	Q9YGL9, AT2A3_CHICK	Q93084, AT2A3_HUMAN
Q64518, AT2A3_MOUSE	O77696, AT2A3_PIG	P18596, AT2A3_RAT
P86911, AT2A_CHIOP	Q98SH2, AT2B1_CHICK	P20020, AT2B1_HUMAN
G5E829, AT2B1_MOUSE	P23220, AT2B1_PIG	Q00804, AT2B1_RABIT
P11505, AT2B1_RAT	Q01814, AT2B2_HUMAN	Q9R0K7, AT2B2_MOUSE
P58165, AT2B2_OREMO	P11506, AT2B2_RAT	Q16720, AT2B3_HUMAN
Q64568, AT2B3_RAT	D3K0R6, AT2B4_BOVIN	P23634, AT2B4_HUMAN
Q6Q477, AT2B4_MOUSE	Q64542, AT2B4_RAT	P57709, AT2C1_BOVIN
P98194, AT2C1_HUMAN	Q80XR2, AT2C1_MOUSE	Q5R5K5, AT2C1_PONAB
Q64566, AT2C1_RAT	O75185, AT2C2_HUMAN	A7L9Z8, AT2C2_MOUSE
Q8R4C1, AT2C2_RAT	Q7PPA5, ATC1_ANOGA	P54678, ATC1_DICDI
P22700, ATC1_DROME	Q292Q0, ATC1_DROPS	O59868, ATC1_SCHPO
O43108, ATC1_YARLI	P13586, ATC1_YEAST	J9VQQ3, ATC2_CRYNH
Q9HDW7, ATC2_SCHPO	P38929, ATC2_YEAST	O34431, ATCL_BACSU
P37278, ATCL_SYNE7	P35316, ATC_ARTSF	Q08853, ATC_PLAFK
P35315, ATC_TRYBB	Q73E41, BACA1_BACC1	Q47910, CDA_MYROD
P0A505, CTPE_MYCBO	A0R3Y2, CTPE_MYCS2	P9WPT0, CTPE_MYCTO
P9WPT1, CTPE_MYCTU	P92939, ECA1_ARATH	O23087, ECA2_ARATH
Q9SY55, ECA3_ARATH	Q9XES1, ECA4_ARATH	Q42883, ECAP_SOLLC
Q9CFU9, LLCA1_LACLA	Q8Y8Q5, LMCA1_LISMO	G5EFR6, MCA1_CAEEL
Q4WHC8, PMRA_ASPFU	Q4WND5, SRCA_ASPFU

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