Expasy logo

ENZYME

ENZYME entry: EC 7.2.4.5

Accepted Name
glutaconyl-CoA decarboxylase
Alternative Name(s)
4-carboxybut-2-enoyl-CoA carboxy-lyase
glutaconyl coenzyme A decarboxylase
pent-2-enoyl-CoA carboxy-lyase
Reaction catalysed
(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)
Comment(s)
  • The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na(+), and acts as a sodium pump.
  • Prior to the Na(+)-dependent decarboxylation, the carboxylate is transferred to biotin in a Na(+)-independent manner.
  • The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
  • Formerly EC 4.1.1.70.
Cross-references
BRENDA7.2.4.5
EC2PDB7.2.4.5
ExplorEnz7.2.4.5
PRIAM enzyme-specific profiles7.2.4.5
KEGG Ligand Database for Enzyme Nomenclature7.2.4.5
IUBMB Enzyme Nomenclature7.2.4.5
IntEnz7.2.4.5
MEDLINEFind literature relating to 7.2.4.5
MetaCyc7.2.4.5
Rhea expert-curated reactions7.2.4.5
UniProtKB/Swiss-Prot
Q06700, GCDA_ACIFVQ9ZAA6, GCDB_ACIFVQ9ZAA7, GCDC_ACIFV
Q9ZAA8, GCDD_ACIFV

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-