ENZYME entry: EC 7.5.2.6

Accepted Name

ABC-type lipid A-core oligosaccharide transporter

Alternative Name(s)

ATP-dependent lipid A-core flippase

lipid flippase

Reaction catalysed

ATP + H2O + lipid A-core oligosaccharideSide 1 <=> ADP + phosphate + lipid A-core oligosaccharideSide 2

Comment(s)

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway.
Not to be confused with EC 7.5.2.5, which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.

Cross-references

BRENDA

7.5.2.6

EC2PDB

7.5.2.6

ExplorEnz

7.5.2.6

PRIAM enzyme-specific profiles

7.5.2.6

KEGG Ligand Database for Enzyme Nomenclature

7.5.2.6

IUBMB Enzyme Nomenclature

7.5.2.6

IntEnz

7.5.2.6

MEDLINE

Find literature relating to 7.5.2.6

MetaCyc

7.5.2.6

Rhea expert-curated reactions

7.5.2.6

UniProtKB/Swiss-Prot

Q483B6, MSBA1_COLP3	Q480N3, MSBA2_COLP3	Q6F9X0, MSBA_ACIAD
Q21WN9, MSBA_ALBFT	Q0VQP5, MSBA_ALCBS	Q5E0F2, MSBA_ALIF1
Q0A4U4, MSBA_ALKEH	Q5P2S7, MSBA_AROAE	Q7VR44, MSBA_BLOFL
Q492S9, MSBA_BLOPB	Q2KYS6, MSBA_BORA1	Q7WH20, MSBA_BORBR
Q7W9N7, MSBA_BORPA	Q7VWD8, MSBA_BORPE	Q39E73, MSBA_BURL3
Q62IG3, MSBA_BURMA	Q1BUV6, MSBA_BURO1	Q3JUI6, MSBA_BURP1
Q63VX7, MSBA_BURPS	Q2SZW0, MSBA_BURTA	Q1QX69, MSBA_CHRSD
Q7NZU6, MSBA_CHRVO	Q83D84, MSBA_COXBU	Q1LQD3, MSBA_CUPMC
Q46Y89, MSBA_CUPPJ	Q47JR8, MSBA_DECAR	Q6AJW3, MSBA_DESPS
P60753, MSBA_ECO57	Q0TJD9, MSBA_ECOL5	Q8FJB1, MSBA_ECOL6
P60752, MSBA_ECOLI	Q1RDU4, MSBA_ECOUT	Q47908, MSBA_FRANO
Q14JW6, MSBA_FRAT1	Q2A1U9, MSBA_FRATH	Q0BKJ3, MSBA_FRATO
Q5NIG3, MSBA_FRATT	Q7VL52, MSBA_HAEDU	Q4QPI4, MSBA_HAEI8
P44407, MSBA_HAEIN	Q2SIN5, MSBA_HAHCH	Q0I4C5, MSBA_HISS1
Q31FG2, MSBA_HYDCU	Q5QU36, MSBA_IDILO	Q5X498, MSBA_LEGPA
Q5ZUH9, MSBA_LEGPH	Q5WVN2, MSBA_LEGPL	Q65U21, MSBA_MANSM
Q60AA3, MSBA_METCA	Q1GZI0, MSBA_METFK	Q5F4X8, MSBA_NEIG1
Q9JW59, MSBA_NEIMA	Q9JXR3, MSBA_NEIMB	Q3J7R8, MSBA_NITOC
Q142P6, MSBA_PARXL	Q9CMG7, MSBA_PASMU	Q6D437, MSBA_PECAS
Q7N6C6, MSBA_PHOLL	Q6LPK6, MSBA_PHOPR	Q12C33, MSBA_POLSJ
Q48P40, MSBA_PSE14	Q15UY7, MSBA_PSEA6	Q9HUG8, MSBA_PSEAE
Q4KJB2, MSBA_PSEF5	Q3KJ31, MSBA_PSEPF	Q88D92, MSBA_PSEPK
Q87VF3, MSBA_PSESM	Q3IGX5, MSBA_PSET1	Q4ZZ16, MSBA_PSEU2
Q4FS42, MSBA_PSYA2	Q1QBW0, MSBA_PSYCK	Q8XXB6, MSBA_RALN1
Q21NS8, MSBA_SACD2	Q57R14, MSBA_SALCH	Q5PGH0, MSBA_SALPA
P63360, MSBA_SALTI	P63359, MSBA_SALTY	Q12M46, MSBA_SHEDO
Q080T2, MSBA_SHEFN	Q8EDF0, MSBA_SHEON	Q0HHH4, MSBA_SHESM
Q0HTS8, MSBA_SHESR	Q31YT6, MSBA_SHIBS	Q32E34, MSBA_SHIDS
Q83LP0, MSBA_SHIFL	Q3Z3K7, MSBA_SHISS	Q2NUA5, MSBA_SODGM
Q2LVL0, MSBA_SYNAS	Q3SFZ6, MSBA_THIDA	Q9KQW9, MSBA_VIBCH
Q87R16, MSBA_VIBPA	Q8DAV2, MSBA_VIBVU	Q7MJ07, MSBA_VIBVY
Q8D2U8, MSBA_WIGBR	Q8PKS5, MSBA_XANAC	Q3BTC8, MSBA_XANC5
Q4UV65, MSBA_XANC8	Q8P8W4, MSBA_XANCP	Q2P3E7, MSBA_XANOM
Q5H0H0, MSBA_XANOR	Q9PEE7, MSBA_XYLFA	Q87EF0, MSBA_XYLFT
Q1CA68, MSBA_YERPA	Q8ZGA9, MSBA_YERPE	Q1CGH0, MSBA_YERPN
Q66CI3, MSBA_YERPS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.5.2.-
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