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ENZYME

ENZYME entry: EC 7.6.2.2

Accepted Name
ABC-type xenobiotic transporter
Alternative Name(s)
ATP phosphohydrolase (steroid-exporting)
MDR protein
multidrug-resistance protein
PDR protein
P-glycoprotein
pleiotropic-drug-resistance protein
steroid-transporting ATPase
xenobiotic-transporting ATPase
Reaction catalysed
ATP + H2O + xenobioticSide 1 <=> ADP + phosphate + xenobioticSide 2
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1).
  • Formerly EC 3.6.3.44.
Cross-references
BRENDA7.6.2.2
EC2PDB7.6.2.2
ExplorEnz7.6.2.2
PRIAM enzyme-specific profiles7.6.2.2
KEGG Ligand Database for Enzyme Nomenclature7.6.2.2
IUBMB Enzyme Nomenclature7.6.2.2
IntEnz7.6.2.2
MEDLINEFind literature relating to 7.6.2.2
MetaCyc7.6.2.2
Rhea expert-curated reactions7.6.2.2
UniProtKB/Swiss-Prot
Q9LYS2, AB10C_ARATHQ9C8H1, AB11C_ARATHQ9C8H0, AB12C_ARATH
Q9SKX0, AB13C_ARATHQ9LZJ5, AB14C_ARATHQ7FB56, AB15C_ARATH
Q9C8G9, AB1C_ARATHQ42093, AB2C_ARATHQ9LK64, AB3C_ARATH
Q7DM58, AB4C_ARATHQ7GB25, AB5C_ARATHQ8VZZ4, AB6C_ARATH
Q9LK62, AB7C_ARATHQ8LGU1, AB8C_ARATHQ9M1C7, AB9C_ARATH
Q9P7V2, ABC4_SCHPOQ99758, ABCA3_HUMANQ8R420, ABCA3_MOUSE
A0A0G2K1Q8, ABCA3_RATQ2M3G0, ABCB5_HUMANB5X0E4, ABCB5_MOUSE
Q4GZT4, ABCG2_BOVINQ9UNQ0, ABCG2_HUMANQ5MB13, ABCG2_MACMU
Q7TMS5, ABCG2_MOUSEQ8MIB3, ABCG2_PIGQ80W57, ABCG2_RAT
Q9CHL8, LMRA_LACLAP97046, LMRA_LACLMP57551, MDLA_BUCAI
Q8K985, MDLA_BUCAPQ89A97, MDLA_BUCBPP77265, MDLA_ECOLI
P57552, MDLB_BUCAIQ8K984, MDLB_BUCAPQ89A96, MDLB_BUCBP
P0AAG7, MDLB_ECO57P0AAG6, MDLB_ECOL6P0AAG5, MDLB_ECOLI
P21447, MDR1A_MOUSEP06795, MDR1B_MOUSEP21448, MDR1_CRIGR
P16875, MDR1_ENTH1P08183, MDR1_HUMANQ06034, MDR1_LEIEN
P43245, MDR1_RATP21449, MDR2_CRIGRP16876, MDR3_ENTH1
Q00449, MDR49_DROMEP16877, MDR4_ENTH1Q00748, MDR65_DROME
P21441, MDR_LEITAP13568, MDR_PLAFFQ8HXQ5, MRP1_BOVIN
Q6UR05, MRP1_CANLFQ5F364, MRP1_CHICKP33527, MRP1_HUMAN
Q864R9, MRP1_MACFAO35379, MRP1_MOUSEQ8CG09, MRP1_RAT
Q92887, MRP2_HUMANQ8VI47, MRP2_MOUSEQ28689, MRP2_RABIT
Q63120, MRP2_RATO15438, MRP3_HUMANB2RX12, MRP3_MOUSE
O88563, MRP3_RATO15439, MRP4_HUMANE9Q236, MRP4_MOUSE
F1M3J4, MRP4_RATO15440, MRP5_HUMANQ9R1X5, MRP5_MOUSE
Q9QYM0, MRP5_RATQ5T3U5, MRP7_HUMANQ8R4P9, MRP7_MOUSE
Q96J66, MRP8_HUMANP34712, PGP1_CAEELP34713, PGP3_CAEEL
Q9PT60, RBP1A_XENLAQ15311, RBP1_HUMANQ62172, RBP1_MOUSE
Q62796, RBP1_RATQ6Q876, SIRA_LEPMC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.-.-
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