ID   7.6.2.3
DE   ABC-type glutathione-S-conjugate transporter.
AN   glutathione-S-conjugate-translocating ATPase.
AN   multidrug resistance-associated protein 1.
AN   YBT1 (gene name).
AN   YCF1 (gene name).
CA   an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted
CA   glutathione(out) + H(+) + phosphate.
CC   -!- A eukaryotic ATP-binding cassette (ABC) type transporter that
CC       mediates the transport of glutathione-S-conjugates.
CC   -!- The mammalian enzyme, which also transports some glucuronides,
CC       exports the substrates out of the cell, while plant and fungal
CC       transporters export them into the vacuole.
CC   -!- Over-expression confers resistance to anticancer drugs by their
CC       efficient exportation in glutathione-S-conjugate form.
DR   Q8HXQ5, MRP1_BOVIN ;  Q6UR05, MRP1_CANLF ;  Q5F364, MRP1_CHICK ;
DR   P33527, MRP1_HUMAN ;  Q864R9, MRP1_MACFA ;  O35379, MRP1_MOUSE ;
DR   Q8CG09, MRP1_RAT   ;  Q92887, MRP2_HUMAN ;  Q8VI47, MRP2_MOUSE ;
DR   Q28689, MRP2_RABIT ;  Q63120, MRP2_RAT   ;  O15438, MRP3_HUMAN ;
DR   B2RX12, MRP3_MOUSE ;  O88563, MRP3_RAT   ;  O15439, MRP4_HUMAN ;
DR   E9Q236, MRP4_MOUSE ;  F1M3J4, MRP4_RAT   ;  O95255, MRP6_HUMAN ;
DR   Q9R1S7, MRP6_MOUSE ;  O88269, MRP6_RAT   ;  Q5T3U5, MRP7_HUMAN ;
DR   Q8R4P9, MRP7_MOUSE ;  Q96J66, MRP8_HUMAN ;  Q9PT60, RBP1A_XENLA;
DR   Q15311, RBP1_HUMAN ;  Q62172, RBP1_MOUSE ;  Q62796, RBP1_RAT   ;
DR   P39109, YCFI_YEAST ;  P53049, YOR1_YEAST ;
//