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ENZYME entry: EC 22.214.171.124
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|Farnesyl diphosphate + protein-cysteine <=> S-farnesyl protein + diphosphate|
- This enzyme, along with EC 126.96.36.199 and EC 188.8.131.52, constitutes the
protein prenyltransferase family of enzymes.
- Catalyzes the formation of a thioether linkage between the C-1 of an
isoprenyl group and a cysteine residue fourth from the C-terminus of
- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
where the terminal residue, X, is preferably serine, methionine,
alanine or glutamine; leucine makes the protein a substrate for
- The enzymes are relaxed in specificity for A(1), but cannot act if
A(2) is aromatic.
- Substrates of the prenyltransferases include Ras, Rho, Rab, other
Ras-related small GTP-binding proteins, gamma-subunits of
heterotrimeric G-proteins, nuclear lamins, centromeric proteins and
many proteins involved in visual signal transduction.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|Q9LX33, FNTA_ARATH; ||P29702, FNTA_BOVIN; ||Q9Y765, FNTA_CANAX; |
|Q54RT9, FNTA_DICDI; ||P49354, FNTA_HUMAN; ||Q61239, FNTA_MOUSE; |
|O24304, FNTA_PEA; ||Q04631, FNTA_RAT; ||O60052, FNTA_SCHPO; |
|P93227, FNTA_SOLLC; ||P29703, FNTA_YEAST; ||Q38920, FNTB_ARATH; |
|P49355, FNTB_BOVIN; ||Q55D51, FNTB_DICDI; ||P49356, FNTB_HUMAN; |
|Q8K2I1, FNTB_MOUSE; ||Q04903, FNTB_PEA; ||Q02293, FNTB_RAT; |
|O13782, FNTB_SCHPO; ||P22007, FNTB_YEAST; |
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