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ENZYME entry: EC 3.5.1.88

Accepted Name
Peptide deformylase.
Alternative Name(s)
PDF.
Polypeptide deformylase.
Reaction catalysed
Formyl-L-methionyl peptide + H(2)O <=> formate + methionyl peptide
Cofactor(s)
Fe(2+).
Comment(s)
  • Requires at least a dipeptide for an efficient rate of reaction.
  • N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
  • Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.
Cross-references
BRENDA3.5.1.88
EC2PDB3.5.1.88
ExplorEnz3.5.1.88
PRIAM enzyme-specific profiles3.5.1.88
KEGG Ligand Database for Enzyme Nomenclature3.5.1.88
IUBMB Enzyme Nomenclature3.5.1.88
IntEnz3.5.1.88
MEDLINEFind literature relating to 3.5.1.88
MetaCyc3.5.1.88
UniProtKB/Swiss-Prot
Q9FV53, DEF1A_ARATH;  B6RGY0, DEF1A_ORYSJ;  Q9FUZ0, DEF1A_SOLLC;  
Q9FUZ2, DEF1B_ARATH;  Q5VNN5, DEF1B_ORYSJ;  Q9FV54, DEF1B_SOLLC;  
Q81WH1, DEF1_BACAN;  Q819U0, DEF1_BACCR;  P94462, DEF1_BACSU;  
Q8G534, DEF1_BIFLO;  Q7WQS9, DEF1_BORBR;  Q7W1V3, DEF1_BORPA;  
Q7W0Q0, DEF1_BORPE;  A0A0H3KB98, DEF1_BURM1;  O05100, DEF1_CLOAB;  
Q8XJL2, DEF1_CLOPE;  Q8FT51, DEF1_COREF;  Q8NQ46, DEF1_CORGL;  
Q83CV9, DEF1_COXBU;  Q7NJV3, DEF1_GLOVI;  Q82TW4, DEF1_NITEU;  
Q8YSK6, DEF1_NOSS1;  Q7V8G6, DEF1_PROMM;  Q88RR1, DEF1_PSEPK;  
Q88B43, DEF1_PSESM;  Q8Y3B0, DEF1_RALSO;  Q92IZ1, DEF1_RICCN;  
Q8EKQ8, DEF1_SHEON;  Q82IV0, DEF1_STRAW;  Q9RD27, DEF1_STRCO;  
Q9KVU3, DEF1_VIBCH;  Q87KD5, DEF1_VIBPA;  Q8DDE3, DEF1_VIBVU;  
Q7MCQ2, DEF1_VIBVY;  Q8PGV2, DEF1_XANAC;  Q8PCN7, DEF1_XANCP;  
Q81MQ9, DEF2_BACAN;  Q819K2, DEF2_BACCR;  Q45495, DEF2_BACSU;  
Q8G487, DEF2_BIFLO;  Q7WG25, DEF2_BORBR;  Q7W4K0, DEF2_BORPA;  
Q7VS88, DEF2_BORPE;  Q97G95, DEF2_CLOAB;  Q8XJX0, DEF2_CLOPE;  
Q8FMD0, DEF2_COREF;  Q8NM41, DEF2_CORGL;  Q83AK6, DEF2_COXBU;  
O31410, DEF2_GEOSE;  Q7NIF5, DEF2_GLOVI;  Q82TC8, DEF2_NITEU;  
Q8YVH1, DEF2_NOSS1;  Q7V5F9, DEF2_PROMM;  Q88EA7, DEF2_PSEPK;  
Q886I1, DEF2_PSESM;  Q8XZJ6, DEF2_RALSO;  Q92JI7, DEF2_RICCN;  
Q8EHZ2, DEF2_SHEON;  Q826Q0, DEF2_STRAW;  Q9FCA2, DEF2_STRCO;  
Q9KN16, DEF2_VIBCH;  Q87I22, DEF2_VIBPA;  Q8D5P5, DEF2_VIBVU;  
Q7MGK6, DEF2_VIBVY;  Q8PG20, DEF2_XANAC;  Q8P4F9, DEF2_XANCP;  
Q8EE60, DEF3_SHEON;  Q825U9, DEF3_STRAW;  Q9XAQ2, DEF3_STRCO;  
Q9K4A0, DEF4_STRCO;  Q9HBH1, DEFM_HUMAN;  B0VNL8, DEF_ACIBS;  
A0LUE1, DEF_ACIC1;  C1F541, DEF_ACIC5;  B3GYT7, DEF_ACTP7;  
A4ST57, DEF_AERS4;  C4ZEV9, DEF_AGARV;  Q8UID1, DEF_AGRFC;  
Q0VTE1, DEF_ALCBS;  B6EP21, DEF_ALISL;  Q0A5B9, DEF_ALKEH;  
A6TRW8, DEF_ALKMQ;  B4S291, DEF_ALTMD;  B3ETT4, DEF_AMOA5;  
O66847, DEF_AQUAE;  C1DFV8, DEF_AZOVD;  Q5LEQ9, DEF_BACFN;  
Q64VP5, DEF_BACFR;  Q9K9I9, DEF_BACHD;  Q5WFA2, DEF_BACSK;  
Q8AAP4, DEF_BACTN;  A6L7J9, DEF_BACV8;  A1UUB4, DEF_BARBK;  
Q6G5F0, DEF_BARHE;  Q6G1G6, DEF_BARQU;  A9ILK4, DEF_BART1;  
Q1LT56, DEF_BAUCH;  A1A2Z1, DEF_BIFAA;  Q7VQC0, DEF_BLOFL;  
Q493I1, DEF_BLOPB;  O51092, DEF_BORBU;  Q89BN9, DEF_BRADU;  
C0QZQ2, DEF_BRAHW;  A5ESQ7, DEF_BRASB;  A4YLB9, DEF_BRASO;  
P63913, DEF_BRUME;  P63914, DEF_BRUSU;  B8D9R9, DEF_BUCA5;  
P57563, DEF_BUCAI;  Q8K975, DEF_BUCAP;  B8D821, DEF_BUCAT;  
P59493, DEF_BUCBP;  Q057D2, DEF_BUCCC;  B9MR36, DEF_CALBD;  
Q8R9T0, DEF_CALS4;  Q9PIT8, DEF_CAMJE;  Q3AC18, DEF_CARHZ;  
B8GYE3, DEF_CAUCN;  Q9ABF5, DEF_CAUCR;  B0T1S9, DEF_CAUSK;  
B3PGY7, DEF_CELJU;  Q11LC7, DEF_CHESB;  A9WHG7, DEF_CHLAA;  
Q5L6G8, DEF_CHLAB;  B8G5R5, DEF_CHLAD;  Q823U4, DEF_CHLCV;  
Q253S4, DEF_CHLFF;  B3EE19, DEF_CHLL2;  Q3B2U9, DEF_CHLL7;  
Q9PK41, DEF_CHLMU;  B3QPU5, DEF_CHLP8;  B3EPG5, DEF_CHLPB;  
A1BHK0, DEF_CHLPD;  A4SFP2, DEF_CHLPM;  Q9Z6J2, DEF_CHLPN;  
B9LBS4, DEF_CHLSY;  B0B7S2, DEF_CHLT2;  Q3KM05, DEF_CHLTA;  
B0BBY7, DEF_CHLTB;  Q8KCG7, DEF_CHLTE;  O84357, DEF_CHLTR;  
Q1QTJ5, DEF_CHRSD;  Q7NQ75, DEF_CHRVO;  A8AQI1, DEF_CITK8;  
O08450, DEF_CLOB8;  B2V4B1, DEF_CLOBA;  Q895Q2, DEF_CLOTE;  
A3DCX4, DEF_CLOTH;  A7MPE9, DEF_CROS8;  Q11X86, DEF_CYTH3;  
Q3Z8F6, DEF_DEHM1;  A5FRA7, DEF_DEHMB;  Q3ZXA9, DEF_DEHMC;  
Q9RRQ4, DEF_DEIRA;  B8FHH0, DEF_DESAA;  C0QI55, DEF_DESAH;  
B1I504, DEF_DESAP;  B8FS81, DEF_DESHD;  Q24U09, DEF_DESHY;  
A8ZUK5, DEF_DESOH;  Q6AQ98, DEF_DESPS;  A5EWL8, DEF_DICNV;  
B5YF46, DEF_DICT6;  B8E0X7, DEF_DICTD;  B7UK10, DEF_ECO27;  
B7MCQ2, DEF_ECO45;  B7LHY3, DEF_ECO55;  P0A6K5, DEF_ECO57;  
B5YT06, DEF_ECO5E;  B7NLK6, DEF_ECO7I;  B7N171, DEF_ECO81;  
B7M0Z2, DEF_ECO8A;  C4ZUE1, DEF_ECOBW;  B1X6D9, DEF_ECODH;  
A8A591, DEF_ECOHS;  A1AGH8, DEF_ECOK1;  Q0TCH5, DEF_ECOL5;  
P0A6K4, DEF_ECOL6;  B1IQ13, DEF_ECOLC;  P0A6K3, DEF_ECOLI;  
B7NDQ8, DEF_ECOLU;  B6I200, DEF_ECOSE;  B1LGP3, DEF_ECOSM;  
Q1R646, DEF_ECOUT;  C5BF17, DEF_EDWI9;  B2KD65, DEF_ELUMP;  
A4WF95, DEF_ENT38;  Q82ZJ0, DEF_ENTFA;  B2VK93, DEF_ERWT9;  
Q2NCT3, DEF_ERYLH;  B7LRQ3, DEF_ESCF3;  B0S139, DEF_FINM2;  
A5FGV5, DEF_FLAJ1;  A6H0E7, DEF_FLAPJ;  A8LE21, DEF_FRASN;  
Q8REF0, DEF_FUSNN;  A0M3P3, DEF_GRAFK;  Q7VKK9, DEF_HAEDU;  
Q4QMV6, DEF_HAEI8;  A5UEB4, DEF_HAEIE;  A5UH92, DEF_HAEIG;  
P44786, DEF_HAEIN;  B8F726, DEF_HAEPS;  Q0I181, DEF_HAES1;  
Q2SQX1, DEF_HAHCH;  B8CWS6, DEF_HALOH;  C4K6Y0, DEF_HAMD5;  
Q17XD4, DEF_HELAH;  Q7VIN5, DEF_HELHP;  B0TGS8, DEF_HELMI;  
B6JM24, DEF_HELP2;  B5Z7F5, DEF_HELPG;  Q1CT77, DEF_HELPH;  
Q9ZL51, DEF_HELPJ;  B2UT38, DEF_HELPS;  P56419, DEF_HELPY;  
B0UWZ5, DEF_HISS2;  Q31J84, DEF_HYDCU;  Q0C4V1, DEF_HYPNA;  
Q5QXI5, DEF_IDILO;  B5XNC4, DEF_KLEP3;  A6TEU0, DEF_KLEP7;  
Q03QL3, DEF_LACBA;  B3WE13, DEF_LACCB;  Q1GAR4, DEF_LACDA;  
Q04B51, DEF_LACDB;  B2GBA3, DEF_LACF3;  Q042S1, DEF_LACGA;  
A8YUR0, DEF_LACH4;  Q74JW2, DEF_LACJO;  Q48661, DEF_LACLA;  
Q039N7, DEF_LACP3;  A9KM99, DEF_LACP7;  Q88VB2, DEF_LACPL;  
A5VJ71, DEF_LACRD;  B2G6P1, DEF_LACRJ;  Q1WU76, DEF_LACS1;  
Q38WP3, DEF_LACSS;  B0SHH1, DEF_LEPBA;  Q04RW4, DEF_LEPBJ;  
Q051Q7, DEF_LEPBL;  B0SQM2, DEF_LEPBP;  Q72S74, DEF_LEPIC;  
Q93LE9, DEF_LEPIN;  Q92CX8, DEF_LISIN;  C1L1X2, DEF_LISMC;  
Q721B5, DEF_LISMF;  B8DCF7, DEF_LISMH;  Q8Y866, DEF_LISMO;  
A0AHG3, DEF_LISW6;  B9EB04, DEF_MACCJ;  Q65QF2, DEF_MANSM;  
Q0ASK2, DEF_MARMM;  B3DUG9, DEF_METI4;  B8ENG6, DEF_METSB;  
P94601, DEF_MICDP;  Q2RK25, DEF_MOOTA;  B1MIN9, DEF_MYCA9;  
Q7U206, DEF_MYCBO;  A1KFQ1, DEF_MYCBP;  C1AKA5, DEF_MYCBT;  
Q7NAK8, DEF_MYCGA;  P47352, DEF_MYCGE;  A4T2T4, DEF_MYCGI;  
B8ZSF6, DEF_MYCLB;  Q9CBI2, DEF_MYCLE;  B2HQN4, DEF_MYCMM;  
Q73T03, DEF_MYCPA;  Q8EVJ8, DEF_MYCPE;  P75527, DEF_MYCPN;  
Q98PN3, DEF_MYCPU;  A0QQP8, DEF_MYCS2;  A3PTZ4, DEF_MYCSJ;  
A1UAD9, DEF_MYCSK;  Q1BEJ4, DEF_MYCSS;  A5TZF5, DEF_MYCTA;  
P9WIJ2, DEF_MYCTO;  P9WIJ3, DEF_MYCTU;  A0PNK2, DEF_MYCUA;  
A1T320, DEF_MYCVP;  B2A2K1, DEF_NATTJ;  B9L6X1, DEF_NAUPA;  
Q5F5P6, DEF_NEIG1;  A9M464, DEF_NEIM0;  P63915, DEF_NEIMA;  
P63916, DEF_NEIMB;  A1KRE5, DEF_NEIMF;  Q2GE16, DEF_NEOSM;  
Q1QH78, DEF_NITHX;  Q3J6U0, DEF_NITOC;  Q2G491, DEF_NOVAD;  
Q8ER96, DEF_OCEIH;  B6JJP8, DEF_OLICO;  B1ZMD5, DEF_OPITP;  
A5CF65, DEF_ORITB;  B3CTU1, DEF_ORITI;  A6L9R8, DEF_PARD8;  
P57948, DEF_PASMU;  Q6D002, DEF_PECAS;  C6DFR5, DEF_PECCP;  
Q03F09, DEF_PEDPA;  B4SBG6, DEF_PELPB;  A5D1C0, DEF_PELTS;  
Q4FNG1, DEF_PELUB;  B4RDT8, DEF_PHEZH;  Q7MYI2, DEF_PHOLL;  
B1XSN2, DEF_POLNS;  B2RMJ1, DEF_PORG3;  Q7MT07, DEF_PORGI;  
B4S9B9, DEF_PROA2;  A2BZN6, DEF_PROM1;  A2BU25, DEF_PROM5;  
Q31DB4, DEF_PROM9;  Q7VED2, DEF_PROMA;  Q7V3K7, DEF_PROMP;  
A2BNK7, DEF_PROMS;  Q46HV9, DEF_PROMT;  Q9I7A8, DEF_PSEAE;  
Q3IDI2, DEF_PSEHT;  A8F524, DEF_PSELT;  A4XNB3, DEF_PSEMY;  
A4VFH8, DEF_PSEU5;  Q4FVQ4, DEF_PSYA2;  Q1QET1, DEF_PSYCK;  
A5WBG1, DEF_PSYWF;  Q98D52, DEF_RHILO;  Q92SH6, DEF_RHIME;  
Q7UHZ5, DEF_RHOBA;  C1B0D9, DEF_RHOOB;  Q2J2C6, DEF_RHOP2;  
Q07TX0, DEF_RHOP5;  Q6NC51, DEF_RHOPA;  Q21B62, DEF_RHOPB;  
Q13F18, DEF_RHOPS;  B3QCH1, DEF_RHOPT;  A8GMJ8, DEF_RICAH;  
A8EXV2, DEF_RICCK;  Q9ZDV8, DEF_RICPR;  Q68XG1, DEF_RICTY;  
A7NPM9, DEF_ROSCS;  A5US58, DEF_ROSS1;  Q21PV5, DEF_SACD2;  
B5F7R3, DEF_SALA4;  A9MN80, DEF_SALAR;  Q57J64, DEF_SALCH;  
B5FJI2, DEF_SALDC;  B5R1E3, DEF_SALEP;  B5RH49, DEF_SALG2;  
B4TJX7, DEF_SALHS;  B4SUQ8, DEF_SALNS;  Q5PIT8, DEF_SALPA;  
A9N8B1, DEF_SALPB;  B5BGV3, DEF_SALPK;  Q2S316, DEF_SALRD;  
B4TXB0, DEF_SALSV;  Q8Z1W9, DEF_SALTI;  Q8ZLM7, DEF_SALTY;  
A8GKG5, DEF_SERP5;  B2U2Q4, DEF_SHIB3;  Q31VZ0, DEF_SHIBS;  
Q32B63, DEF_SHIDS;  Q0T016, DEF_SHIF8;  Q83PZ1, DEF_SHIFL;  
Q3YWX3, DEF_SHISS;  Q2NQQ4, DEF_SODGM;  A5VDM3, DEF_SPHWW;  
Q5HGZ3, DEF_STAAC;  P68825, DEF_STAAM;  P99077, DEF_STAAN;  
Q6GHZ4, DEF_STAAR;  Q6GAC3, DEF_STAAS;  P68826, DEF_STAAU;  
Q8NX78, DEF_STAAW;  Q5HQ78, DEF_STAEQ;  Q8CPN4, DEF_STAES;  
Q3JZ45, DEF_STRA1;  Q8E378, DEF_STRA3;  Q8DXF6, DEF_STRA5;  
C0M9E1, DEF_STRE4;  B4U576, DEF_STREM;  A8AV30, DEF_STRGC;  
B4SKH7, DEF_STRM5;  B2FIR4, DEF_STRMK;  Q8DWC2, DEF_STRMU;  
P68771, DEF_STRP1;  Q04JP7, DEF_STRP2;  P0DC96, DEF_STRP3;  
B5E5U9, DEF_STRP4;  Q5X9V1, DEF_STRP6;  C1C851, DEF_STRP7;  
Q8NZB7, DEF_STRP8;  Q1J9R7, DEF_STRPB;  Q1JJW6, DEF_STRPC;  
Q1JEV7, DEF_STRPD;  Q1J4M3, DEF_STRPF;  A2RGI0, DEF_STRPG;  
B1ICN7, DEF_STRPI;  B8ZL02, DEF_STRPJ;  Q48R93, DEF_STRPM;  
Q9F2F0, DEF_STRPN;  P0DC97, DEF_STRPQ;  B2IQS1, DEF_STRPS;  
B5XIL1, DEF_STRPZ;  Q8DP79, DEF_STRR6;  A4W418, DEF_STRS2;  
C0MFA6, DEF_STRS7;  A4VXS1, DEF_STRSY;  Q5M1R9, DEF_STRT1;  
Q5M6B0, DEF_STRT2;  Q03MP6, DEF_STRTD;  B9DTD6, DEF_STRU0;  
C1CF38, DEF_STRZJ;  C1CLF5, DEF_STRZP;  C1CQR2, DEF_STRZT;  
A8Z5V9, DEF_SULMW;  Q67PR5, DEF_SYMTH;  A0LEJ7, DEF_SYNFM;  
B1XJP0, DEF_SYNP2;  Q7U9D4, DEF_SYNPX;  A5GQU9, DEF_SYNR3;  
Q0I7A5, DEF_SYNS3;  Q3AZU8, DEF_SYNS9;  Q3AHC4, DEF_SYNSC;  
Q0AXL3, DEF_SYNWW;  P73441, DEF_SYNY3;  C5BKQ0, DEF_TERTT;  
Q8DIB4, DEF_THEEB;  P96113, DEF_THEMA;  B9K7G9, DEF_THENN;  
A5ILS1, DEF_THEP1;  B0KA11, DEF_THEP3;  B0K292, DEF_THEPX;  
B9L0C1, DEF_THERP;  B1LB14, DEF_THESQ;  Q72H33, DEF_THET2;  
Q5SLH2, DEF_THET8;  P43522, DEF_THETH;  B5YIL7, DEF_THEYD;  
B8GU11, DEF_THISH;  C4L7Y4, DEF_TOLAT;  O83738, DEF_TREPA;  
B2S3Z6, DEF_TREPS;  Q83HQ3, DEF_TROW8;  Q83GH8, DEF_TROWT;  
B1GZ10, DEF_UNCTG;  B1AJA6, DEF_UREP2;  Q9PQ25, DEF_UREPA;  
A7N121, DEF_VIBCB;  Q5E1Q8, DEF_VIBF1;  B5FCW6, DEF_VIBFM;  
Q8D258, DEF_WIGBR;  Q73IJ6, DEF_WOLPM;  B3CMB1, DEF_WOLPP;  
Q7M7M2, DEF_WOLSU;  Q5GTG9, DEF_WOLTR;  C0R5A2, DEF_WOLWR;  
B2I8S4, DEF_XYLF2;  P63917, DEF_XYLFA;  B0U4M4, DEF_XYLFM;  
P63918, DEF_XYLFT;  A1JRZ1, DEF_YERE8;  A7FNK2, DEF_YERP3;  
Q1C2X9, DEF_YERPA;  B2K504, DEF_YERPB;  Q8ZJ79, DEF_YERPE;  
A9R927, DEF_YERPG;  Q1CCX6, DEF_YERPN;  A4TH23, DEF_YERPP;  
Q664V4, DEF_YERPS;  B1JJH8, DEF_YERPY;  Q9REQ2, DEF_ZYMMO;  

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