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ENZYME

ENZYME entry: EC 1.1.1.103

Accepted Name
L-threonine 3-dehydrogenase
Alternative Name(s)
TDH
Reaction catalysed
L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH
Comment(s)
  • Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine.
  • This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex.
  • In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.
Cross-references
BRENDA1.1.1.103
EC2PDB1.1.1.103
ExplorEnz1.1.1.103
PRIAM enzyme-specific profiles1.1.1.103
KEGG Ligand Database for Enzyme Nomenclature1.1.1.103
IUBMB Enzyme Nomenclature1.1.1.103
IntEnz1.1.1.103
MEDLINEFind literature relating to 1.1.1.103
MetaCyc1.1.1.103
Rhea expert-curated reactions1.1.1.103
UniProtKB/Swiss-Prot
A0KQV6, TDH_AERHHA4SHB7, TDH_AERS4Q5E0F9, TDH_ALIF1
B5ETJ6, TDH_ALIFMB6ESA4, TDH_ALISLB4S298, TDH_ALTMD
B8J714, TDH_ANAD2Q2IJN4, TDH_ANADEA7HEI5, TDH_ANADF
B4UMJ1, TDH_ANASKQ65JE7, TDH_BACLDO31776, TDH_BACSU
A7Z4X0, TDH_BACVZQ2KIR8, TDH_BOVINB1YXP0, TDH_BURA4
A0B459, TDH_BURCHB4EFZ7, TDH_BURCJQ0B5Q1, TDH_BURCM
Q38ZS8, TDH_BURL3A9AR24, TDH_BURM1A3MAC8, TDH_BURM7
A2RZW5, TDH_BURM9Q62EL5, TDH_BURMAA1UXP8, TDH_BURMS
B1K269, TDH_BURO0Q1BK24, TDH_BURO1A3P139, TDH_BURP0
Q3JID4, TDH_BURP1A3NF91, TDH_BURP6Q63PD9, TDH_BURPS
Q2T9E1, TDH_BURTAA4JKG7, TDH_BURVGQ8R7K0, TDH_CALS4
Q11L77, TDH_CHESBQ7NXH5, TDH_CHRVOA8ARK6, TDH_CITK8
Q48AM4, TDH_COLP3B6J2S1, TDH_COXB2A9KET6, TDH_COXBN
A9NA21, TDH_COXBRQ83F39, TDH_COXBUA7MID0, TDH_CROS8
Q6AAR3, TDH_CUTAKC1D195, TDH_DEIDVQ9RTU4, TDH_DEIRA
A7ZTH0, TDH_ECO24B7ULH2, TDH_ECO27B7MFI0, TDH_ECO45
B7L742, TDH_ECO55Q8XEJ1, TDH_ECO57B5YWB7, TDH_ECO5E
B7NPC5, TDH_ECO7IB7N1S0, TDH_ECO81B7M4A3, TDH_ECO8A
C4ZXK8, TDH_ECOBWB1X950, TDH_ECODHA8A681, TDH_ECOHS
A1AHF3, TDH_ECOK1Q0TBJ0, TDH_ECOL5Q8FCA2, TDH_ECOL6
B1IZH4, TDH_ECOLCP07913, TDH_ECOLIB7NES3, TDH_ECOLU
B6I3J6, TDH_ECOSEB1LK55, TDH_ECOSMQ1R4X4, TDH_ECOUT
C5BB99, TDH_EDWI9A4W529, TDH_ENT38B7LVH6, TDH_ESCF3
B0TYR8, TDH_FRAP2Q14IB6, TDH_FRAT1A7NDM9, TDH_FRATF
Q2A282, TDH_FRATHB2SDJ2, TDH_FRATMA0Q5K3, TDH_FRATN
Q0BKV5, TDH_FRATOQ5NGW4, TDH_FRATTA4IZ92, TDH_FRATW
Q5QUN8, TDH_IDILOB5XTI4, TDH_KLEP3A6TFL2, TDH_KLEP7
Q5X748, TDH_LEGPAA5IGK7, TDH_LEGPCQ5ZXM9, TDH_LEGPH
Q5WYJ7, TDH_LEGPLA6W1W3, TDH_MARMSQ8K3F7, TDH_MOUSE
B2JPU0, TDH_PARP8B2T7X5, TDH_PARPJQ6MD15, TDH_PARUW
Q13SG2, TDH_PARXLQ6DAT5, TDH_PECASC6DIA7, TDH_PECCP
Q7MY48, TDH_PHOLLQ6LRD9, TDH_PHOPRQ8MIR0, TDH_PIG
B4F134, TDH_PROMHQ15ZU4, TDH_PSEA6Q3IHW0, TDH_PSET1
A1SVW5, TDH_PSYINQ9UYX0, TDH_PYRABQ8U259, TDH_PYRFU
O58389, TDH_PYRHOB3PUI4, TDH_RHIE6Q2K618, TDH_RHIEC
Q1MDT5, TDH_RHIJ3Q983J7, TDH_RHILOB5ZXE7, TDH_RHILW
Q52998, TDH_RHIMEB9J738, TDH_RHIR8Q5LN53, TDH_RUEPO
A4FND4, TDH_SACENB5EXC3, TDH_SALA4A9MKQ8, TDH_SALAR
Q57IC5, TDH_SALCHB5FLI6, TDH_SALDCB5R5E1, TDH_SALEP
B5RGH0, TDH_SALG2B4T9A1, TDH_SALHSB4SXB9, TDH_SALNS
Q5PC07, TDH_SALPAA9MVL0, TDH_SALPBC0Q1V0, TDH_SALPC
B5BHZ1, TDH_SALPKB4TZV9, TDH_SALSVQ8Z2F4, TDH_SALTI
Q8ZL52, TDH_SALTYA8GLC6, TDH_SERP5A1S1Q3, TDH_SHEAM
B8EDS6, TDH_SHEB2A3CYN0, TDH_SHEB5A6WUG6, TDH_SHEB8
A9KWY0, TDH_SHEB9Q07W50, TDH_SHEFNB0TNM4, TDH_SHEHH
A3QJC8, TDH_SHELPQ8E8J1, TDH_SHEONA8GYP8, TDH_SHEPA
A4YCC5, TDH_SHEPCA0L2Q3, TDH_SHESAA8FPE0, TDH_SHESH
Q0HDA3, TDH_SHESMQ0HPI5, TDH_SHESRA1RE07, TDH_SHESW
B1KL24, TDH_SHEWMB2U5D5, TDH_SHIB3Q31V06, TDH_SHIBS
Q329N8, TDH_SHIDSQ0SYE5, TDH_SHIF8P59409, TDH_SHIFL
Q3YVY1, TDH_SHISSC3MFH1, TDH_SINFNA6UBM6, TDH_SINMW
Q02BT1, TDH_SOLUEQ82MN2, TDH_STRAWQ9L233, TDH_STRCO
B1VWE7, TDH_STRGGB2FQN4, TDH_STRMKQ67N85, TDH_SYMTH
Q5JI69, TDH_THEKOB6YTJ5, TDH_THEONQ72L62, TDH_THET2
Q5SKS4, TDH_THET8B7VR52, TDH_VIBA3A5F0N6, TDH_VIBC3
Q9KL62, TDH_VIBCHC3LWF0, TDH_VIBCMP59410, TDH_VIBPA
Q8D442, TDH_VIBVUQ7MFL5, TDH_VIBVYQ8PNN2, TDH_XANAC
Q4URI9, TDH_XANC8B0RU31, TDH_XANCBO34268, TDH_XANCP
Q3BWT0, TDH_XANE5Q2NZP2, TDH_XANOMQ5GWI3, TDH_XANOR
A1JHX8, TDH_YERE8A7FCU5, TDH_YERP3Q1C278, TDH_YERPA
B2JYP4, TDH_YERPBQ8ZJN2, TDH_YERPEA9R685, TDH_YERPG
Q1CD13, TDH_YERPNA4TSC6, TDH_YERPPQ66GC5, TDH_YERPS
B1JQW2, TDH_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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