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ENZYME entry: EC 1.1.1.141

Accepted Name
15-hydroxyprostaglandin dehydrogenase (NAD(+)).
Alternative Name(s)
15-hydroxyprostaglandin dehydrogenase.
Reaction catalysed
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) <=> (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
Comment(s)
Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197).
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.141
EC2PDB1.1.1.141
ExplorEnz1.1.1.141
PRIAM enzyme-specific profiles1.1.1.141
KEGG Ligand Database for Enzyme Nomenclature1.1.1.141
IUBMB Enzyme Nomenclature1.1.1.141
IntEnz1.1.1.141
MEDLINEFind literature relating to 1.1.1.141
MetaCyc1.1.1.141
UniProtKB/Swiss-Prot
Q8MI29, CBR1_MACFA;  Q3T0C2, PGDH_BOVIN;  P70684, PGDH_CAVPO;  
P15428, PGDH_HUMAN;  Q8MJY8, PGDH_MACFA;  Q8VCC1, PGDH_MOUSE;  
O08699, PGDH_RAT;  

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